Therapeutic Action
Antimalarial
Source page 273
Loading InternPractice…
Individual generic drug information
Extracted information for QUININE only.
Antimalarial
Source page 273
Treatment of uncomplicated falciparum malaria, when artemisinin-based combinations cannot be used Completion treatment following parenteral therapy with quinine for severe falciparum malaria, when artemisinin-based combinations cannot be used
Source page 273
Extracted information for QUININE only.
May cause: headache, skin rash; visual, auditory and gastrointestinal disturbances. Do not exceed indicated doses: risk of toxicity in the event of overdose. Avoid combination with drugs that prolong QT interval: amiodarone, other antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc. If the patient vomits within 30 minutes after administration, re-administer the full dose. If the patient vomits between 30 minutes and 1 hour after administration, re-administer half of the dose. Pregnancy: no contra-indication; it is recommended to administer quinine in combination with clindamycin if possible. Breast-feeding: no contra-indication
Source pages 273, 274
Extracted information for QUININE only.
300 mg quinine sulfate tablet
Source page 273
Dosage is expressed in terms of salt. Except for quinine bisulfate, the dosage is the same for all quinine salts (sulfate, hydrochloride, dihydrochloride): Child and adult < 50 kg: 10 mg/kg 3 times daily at 8-hour intervals for 7 days Adult ≥ 50 kg: 600 mg 3 times daily at 8-hour intervals for 7 days Age Weight 300 mg tablet 5 months to < 2 years 7 to < 12 kg ¼ tab x 3 2 to < 8 years 12 to < 25 kg ½ tab x 3 8 to < 11 years 25 to < 35 kg 1 tab x 3 11 to < 14 years 35 to < 50 kg 1½ tab x 3 ≥ 14 years ≥ 50 kg 2 tab x 3
Source page 273
Extracted information for QUININE only.
10 mg of quinine sulfate or hydrochloride or dihydrochloride = 8 mg of quinine base; 14 mg of quinine bisulfate = 8 mg of quinine base.
Source page 274
– Below 25 °C
Source page 274
Filter the extracted dose blocks for this individual drug.
10 mg/kg 3 times daily at 8-hour intervals for 7 days
Candidate age grouping · source page 273