Therapeutic Action
First line antituberculosis antibacterial (bactericidal activity)
Source page 177
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Individual generic drug information
Extracted information for ISONIAZID only.
First line antituberculosis antibacterial (bactericidal activity)
Source page 177
Tuberculosis, in combination with other antituberculosis antibacterials Latent tuberculosis, as monotherapy or in combination with rifampicin or rifapentine
Source page 177
Extracted information for ISONIAZID only.
Do not administer to patients with severe hepatic impairment. May cause: peripheral neuropathy, especially in malnourished, alcoholic, diabetic, HIV-infected patients; pregnant and breast-feeding women and patients with renal impairment; hepatotoxicity, especially in alcoholic patients or patients with chronic hepatic disease or receiving rifampicin, or over 35 years; hypersensitivity reactions, psychotic reactions, seizures and depression. Monitor liver function in patients with known hepatic disease. If signs of hepatotoxicity (e.g. jaundice) develop, isoniazid should be discontinued until symptoms resolve. Administer with caution and closely monitor patients taking phenytoin, carbamazepine, benzodiazepines (risk of toxicity), warfarin (risk of bleeding). Administer pyridoxine (vitamin B ) in patients at risk of peripheral neuropathy (child: 5 to 10 mg once 6 daily; adult: 10 mg once daily). Pregnancy: no contra-indication. Administer pyridoxine to the mother (10 mg once daily). Breast-feeding: no contra-indication;. Administer pyridoxine to the mother (10 mg once daily) and the infant (5 mg once daily).
Source pages 177, 178
Extracted information for ISONIAZID only.
100 mg and 300 mg tablets 50 mg and 100 mg dispersible tablets
Source page 177
Tuberculosis, latent tuberculosis as monotherapy or in combination with daily rifampicin Child under 30 kg: 10 mg/kg (7 to 15 mg/kg) once daily, on an empty stomach Child 30 kg and over and adult: 5 mg/kg (4 to 6 mg/kg) once daily, on an empty stomach Do not exceed 300 mg daily. Latent tuberculosis in combination with weekly rifapentine Child under 30 kg and over 2 years: 20 to 30 mg/kg once weekly, on an empty stomach Child 30 kg and over and adult: 900 mg once weekly, on an empty stomach Latent tuberculosis in combination with daily rifapentine Child 13 years and over and adult: 300 mg once daily, on an empty stomach
Source page 177
Tuberculosis and latent tuberculosis as monotherapy: according to protocol Latent tuberculosis in combination with daily rifampicin or weekly rifapentine: 3 months Latent tuberculosis in combination with daily rifapentine: 1 month
Source page 177
Extracted information for ISONIAZID only.
For patients sensitive to first-line antituberculosis treatment, isoniazid is given as part of a fixed dose combination. Also comes in fixed dose combination containing 300 mg of rifapentine/300 mg of isoniazid for the treatment of latent tuberculosis in children over 14 years and adults.
Source page 178
– – Below 25 °C
Source page 178
Filter the extracted dose blocks for this individual drug.
5 mg/kg (4 to 6 mg/kg) once daily, on an empty stomach
Candidate age grouping · source page 177
900 mg once weekly, on an empty stomach
Candidate age grouping · source page 177
300 mg once daily, on an empty stomach
Candidate age grouping · source page 177