Therapeutic Action
First line antituberculosis antibacterial (sterilising and bactericidal activity)
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Individual generic drug information
Extracted information for PYRAZINAMIDE only.
First line antituberculosis antibacterial (sterilising and bactericidal activity)
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Tuberculosis, in combination with other antituberculosis antibacterials
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Extracted information for PYRAZINAMIDE only.
Do not administer to patients with hypersensitivity to pyrazinamide, severe hepatic impairment or severe gout. May cause: gout and arthralgias, hepatotoxicity, photosensitivity (limit sun exposure), rash, gastrointestinal disturbances, hypersensitivity reactions. Monitor liver function in patients with known hepatic disease. If signs of hepatotoxicity (e.g. jaundice) develop, pyrazinamide should be discontinued until symptoms resolve. Pregnancy: no contra-indication Breast-feeding: no contra-indication
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Extracted information for PYRAZINAMIDE only.
400 mg tablet 150 mg dispersible tablet
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Child under 30 kg: 35 mg/kg (30 to 40 mg/kg) once daily Child 30 kg and over and adult: 25 mg/kg (20 to 30 mg/kg) once daily Do not exceed 2 g daily. Patient with renal impairment: 25 mg/kg 3 times weekly
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According to protocol
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Extracted information for PYRAZINAMIDE only.
For patients on first-line antituberculosis treatment, pyrazinamide is given as part of a fixed dose combination.
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– – Below 25 °C
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Filter the extracted dose blocks for this individual drug.
25 mg/kg (20 to 30 mg/kg) once daily
Candidate age grouping · source page 267