Drug Action
Risperidone is a dopamine D2, 5-HT2A, alpha1-adrenoceptor, and histamine-1 receptor antagonist.
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Individual generic drug information
Extracted information for Risperidone only.
Risperidone is a dopamine D2, 5-HT2A, alpha1-adrenoceptor, and histamine-1 receptor antagonist.
Source page 443
Schizophrenia and other psychoses in patients tolerant to risperidone by mouth and taking oral risperidone up to 4 mg daily ▶BY DEEP INTRAMUSCULAR INJECTION ▶Adult: Initially 25 mg every 2 weeks, to be administered into the deltoid or gluteal muscle, adjusted in steps of 12.5 mg (max. per dose 50 mg every 2 weeks) at intervals of at least 4 weeks, during initiation risperidone by mouth may need to be continued for 4–6 weeks; risperidone by mouth may also be used during dose adjustment of depot injection Schizophrenia and other psychoses in patients tolerant to risperidone by mouth and taking oral risperidone over 4 mg daily ▶BY DEEP INTRAMUSCULAR INJECTION ▶Adult: Initially 37.5 mg every 2 weeks, adjusted in steps of 12.5 mg (max. per dose 50 mg every 2 weeks) at intervals of at least 4 weeks, during initiation risperidone by mouth may need to be continued for 4–6 weeks; risperidone by mouth may also be used during dose adjustment of depot injection Acute and chronic psychosis ▶BY MOUTH ▶Adult: 2 mg daily in 1–2 divided doses for day 1, then 4 mg daily in 1–2 divided doses for day 2, slower titration is appropriate in some patients, usual dose 4–6 mg daily, doses above 10 mg daily only if benefit considered to outweigh risk; maximum 16 mg per day ▶Elderly: Initially 500 micrograms twice daily, then increased in steps of 500 micrograms twice daily, increased to 1–2 mg twice daily Mania ▶BY MOUTH ▶Adult: Initially 2 mg once daily, then increased in steps of 1 mg daily if required; usual dose 1–6 mg daily ▶Elderly: Initially 500 micrograms twice daily, then increased in steps of 500 micrograms twice daily, increased to 1–2 mg twice daily Short-term treatment (up to 6 weeks) of persistent aggression in patients with moderate to severe Alzheimer’s dementia unresponsive to non- pharmacological interventions and when there is a risk of harm to self or others ▶BY MOUTH ▶Adult: Initially 250 micrograms twice daily, then increased in steps of 250 micrograms twice a day on alternate days, adjusted according to response; usual dose 500 micrograms twice daily (max. per dose 1 mg twice daily)
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GENERAL CAUTIONS Avoid in Acute porphyrias p. 1120. cataract surgery (risk of intra-operative floppy iris syndrome). dehydration. dementia with Lewy bodies. prolactin-dependent tumours SPECIFIC CAUTIONS ▶With intramuscular use when transferring from oral to depot therapy, the dose by mouth should be reduced gradually
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Extracted information for Risperidone only.
SAFE PRACTICE Risperidone has been confused with ropinirole; care must be taken to ensure the correct drug is prescribed and dispensed.
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→Appendix 1: risperidone
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▶Common or very common Anaemia. anxiety. appetite abnormal. asthenia. chest discomfort. conjunctivitis. Nervous system cough. depression. diarrhoea. dyspnoea. epistaxis. fall. fever. gastrointestinal discomfort. headache. hyperglycaemia. hypertension. increased risk of infection . joint disorders. laryngeal pain. muscle spasms. nasal congestion. nausea. oedema. oral disorders. pain. sexual dysfunction. skin reactions. sleep disorders. urinary disorders. vision disorders. weight decreased ▶Uncommon Alopecia. breast abnormalities. cardiac conduction disorders. cerebrovascular insufficiency. chills . coma. concentration impaired. confusion. consciousness impaired. cystitis. diabetes mellitus. dry eye. dysarthria. dysphagia. dysphonia. ear pain. eye disorders. feeling abnormal. flushing. gait abnormal. gastrointestinal disorders. induration. malaise. menstrual cycle irregularities. mood altered. muscle weakness. palpitations. polydipsia. posture abnormal. procedural pain. respiratory disorders. sensation abnormal. syncope. taste altered. thirst. thrombocytopenia. tinnitus. vaginal discharge. vertigo ▶Rare or very rare Angioedema. dandruff. diabetic ketoacidosis. eyelid crusting. glaucoma. hypoglycaemia. hypothermia. jaundice. pancreatitis. peripheral coldness. rhabdomyolysis. SIADH. sleep apnoea. water intoxication . withdrawal syndrome ▶Frequency not known Cardiac arrest
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Use only if potential benefit outweighs risk.
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Use only if potential benefit outweighs risk—small amount present in milk.
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Manufacturer advises caution. Dose adjustments ▶With intramuscular use Manufacturer advises if an oral dose of at least 2 mg daily tolerated, 25 mg as a depot injection can be given every 2 weeks (no information available). ▶With oral use Manufacturer advises dose reduction to half the usual dose, and slower dose titration.
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Dose adjustments Initial and subsequent oral doses should be halved.
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▶With intramuscular use Treatment requires careful monitoring for optimum effect.
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Extracted information for Risperidone only.
▶With oral use Orodispersible tablets should be placed on the tongue, allowed to dissolve and swallowed. Oral liquid may be diluted with any non-alcoholic drink, except tea. ▶With intramuscular use Correct injection technique (including the use of z-track technique) and rotation of injection sites are essential.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral solution Tablet CAUTIONARY AND ADVISORY LABELS 2 ▶Risperidone (Non-proprietary) Risperidone 500 microgram Risperidone 500microgram tablets | 20 tablet P £6.95 DT = £1.68 Risperidone 1 mg Risperidone 1mg tablets | 20 tablet P £10.16 DT = £1.98 | 60 tablet P £5.94–£17.56 Risperidone 2 mg Risperidone 2mg tablets | 60 tablet P £60.10 DT = £5.97 Risperidone 3 mg Risperidone 3mg tablets | 60 tablet P £88.38 DT = £10.87 Risperidone 4 mg Risperidone 4mg tablets | 60 tablet P £116.67 DT = £8.95 Risperidone 6 mg Risperidone 6mg tablets | 28 tablet P £82.50 DT = £49.21 ▶Risperdal (Janssen-Cilag Ltd) Risperidone 500 microgram Risperdal 500microgram tablets | Nervous system 20 tablet P £5.08 DT = £1.68 Risperidone 1 mg Risperdal 1mg tablets | 20 tablet P £8.36 DT = £1.98 | 60 tablet P £17.56 Risperidone 2 mg Risperdal 2mg tablets | 60 tablet P £34.62 DT = £5.97 Risperidone 3 mg Risperdal 3mg tablets | 60 tablet P £50.91 DT = £10.87 Risperidone 4 mg Risperdal 4mg tablets | 60 tablet P £67.20 DT = £8.95 Risperidone 6 mg Risperdal 6mg tablets | 28 tablet P £67.88 DT = £49.21 Oral solution CAUTIONARY AND ADVISORY LABELS 2 ▶Risperidone (Non-proprietary) Risperidone 1 mg per 1 ml Risperidone 1mg/ml oral solution sugar- free | 100 ml P £58.22 DT = £4.04 ▶Risperdal (Janssen-Cilag Ltd) Risperidone 1 mg per 1 ml Risperdal 1mg/ml oral solution sugar- free | 100 ml P £37.01 DT = £4.04 Powder and solvent for suspension for injection ▶Risperdal Consta (Janssen-Cilag Ltd) Risperidone 25 mg Risperdal Consta 25mg powder and solvent for suspension for injection vials | 1 vial P £79.69 DT = £79.69 Risperidone 37.5 mg Risperdal Consta 37.5mg powder and solvent for suspension for injection vials | 1 vial P £111.32 DT = £111.32 Risperidone 50 mg Risperdal Consta 50mg powder and solvent for suspension for injection vials | 1 vial P £142.76 DT = £142.76 Orodispersible tablet CAUTIONARY AND ADVISORY LABELS 2 EXCIPIENTS: May contain Aspartame ▶Risperidone (Non-proprietary) Risperidone 500 microgram Risperidone 500microgram orodispersible tablets sugar-free | 28 tablet P £18.64 DT = £18.28 Risperidone 1 mg Risperidone 1mg orodispersible tablets sugar-free | 28 tablet P £22.50 DT = £22.07 Risperidone 2 mg Risperidone 2mg orodispersible tablets sugar-free | 28 tablet P £39.03 DT = £39.03 Risperidone 3 mg Risperidone 3mg orodispersible tablets sugar-free | 28 tablet P £43.50 DT = £43.50 Risperidone 4 mg Risperidone 4mg orodispersible tablets sugar-free | 28 tablet P £50.29 DT = £50.29 ANTIPSYCHOTICS › SECOND-GENERATION (DEPOT INJECTIONS) eiiii F 401
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Extracted information for Risperidone only.
▶With oral use Patients or carers should be given advice on how to administer risperidone orodispersible tablets and oral liquid (counselling on use of dose syringe advised).
Source page 443
Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
Initially 500 micrograms twice daily, then
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 443
First line only; read the complete Indications and dose section above.
Initially 500 micrograms twice daily, then
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 443