Individual generic drug information

streptomycin

Reference monograph

Part of registered formulation

STREPTOMYCIN SULPHATE

Reference record: Streptomycin
Source: BNF 80 (2020–2021)
Printed source pages: 568
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Streptomycin only.

Indications And Dose

Tuberculosis, resistant to other treatment, in combination with other drugs ▶BY DEEP INTRAMUSCULAR INJECTION ▶Adult: 15 mg/kg daily (max. per dose 1 g), reduce dose in those under 50 kg and those over 40 years Adjunct to doxycycline in brucellosis (administered on expert advice) ▶BY DEEP INTRAMUSCULAR INJECTION ▶Adult: (consult local protocol) Enterococcal endocarditis ▶Adult: (consult local protocol) l UNLICENSED USE Use in tuberculosis is an unlicensed indication.

Source page 568

Safety

Extracted information for Streptomycin only.

Important Safety Information

Side-effects increase after a cumulative dose of 100 g, which should only be exceeded in exceptional circumstances.

Source page 568

Interactions

→Appendix 1: aminoglycosides

Source page 568

Side Effects

Amblyopia. angioedema. Clostridioides difﬁcile colitis. haemolytic anaemia. muscle weakness. ototoxicity. pancytopenia

Source page 568

Renal Impairment

Dose adjustments Should preferably be avoided. If essential, use with great care and consider dose reduction.

Source page 568

Monitoring Requirements

▶One-hour (‘peak’) concentration should be 15–40 mg/litre; pre-dose (‘trough’) concentration should be less than 5 mg/litre (less than 1 mg/litre in renal impairment or in those over 50 years).

Source page 568

Dose and formulations

Extracted information for Streptomycin only.

Medicinal Forms

Forms available from special-order manufacturers include: powder for solution for injection eiiii F 543

Source page 568

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

15 mg/kg daily (max. per dose 1 g), reduce dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 568

Adults

First line only; read the complete Indications and dose section above.

(consult local protocol)

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 568

Adults

First line only; read the complete Indications and dose section above.

(consult local protocol)

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 568

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

streptomycin

Reference monograph

Part of registered formulation

STREPTOMYCIN SULPHATE

Reference record: Streptomycin
Source: BNF 80 (2020–2021)
Printed source pages: 568
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Streptomycin only.

Indications And Dose

Source page 568

Safety

Extracted information for Streptomycin only.

Important Safety Information

Side-effects increase after a cumulative dose of 100 g, which should only be exceeded in exceptional circumstances.

Source page 568

Interactions

→Appendix 1: aminoglycosides

Source page 568

Side Effects

Amblyopia. angioedema. Clostridioides difﬁcile colitis. haemolytic anaemia. muscle weakness. ototoxicity. pancytopenia

Source page 568

Renal Impairment

Dose adjustments Should preferably be avoided. If essential, use with great care and consider dose reduction.

Source page 568

Monitoring Requirements

Source page 568

Dose and formulations

Extracted information for Streptomycin only.

Medicinal Forms

Forms available from special-order manufacturers include: powder for solution for injection eiiii F 543

Source page 568

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

15 mg/kg daily (max. per dose 1 g), reduce dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 568

Adults

First line only; read the complete Indications and dose section above.

(consult local protocol)

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 568

Adults

First line only; read the complete Indications and dose section above.

(consult local protocol)

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 568

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.