Drug Action
Temozolomide is structurally related to dacarbazine.
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Individual generic drug information
Extracted information for Temozolomide only.
Temozolomide is structurally related to dacarbazine.
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Newly diagnosed glioblastoma multiforme in adults (in combination with radiotherapy) and subsequently as monotherapy | Second-line treatment of malignant glioma in adults ▶BY MOUTH ▶Adult: (consult product literature)
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Pneumocystis jirovecii pneumonia—consult product literature for monitoring and prophylaxis requirements
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NICE decisions ▶Temozolomide for the treatment of recurrent malignant glioma (brain cancer) (April 2001) NICE TA23 Temozolomide may be considered for the treatment of recurrent malignant glioma, which has not responded to first-line chemotherapy. www.nice.org.uk/guidance/ta23 ▶Carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma (June 2007) NICE TA121 Temozolomide is an option for the treatment of newly diagnosed glioblastoma multiforme in patients with a WHO performance status of 0 or 1. www.nice.org.uk/guidance/ta121
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Extracted information for Temozolomide only.
RISKS OF INCORRECT DOSING OF ORAL ANTI-CANCER MEDICINES See Cytotoxic drugs p. 938.
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→Appendix 1: alkylating agents
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▶Common or very common Alopecia. anxiety. appetite decreased. arthralgia. asthenia. chills. concentration impaired. confusion. constipation. cough. decreased leucocytes. diarrhoea. dizziness. drowsiness. dysphagia. dyspnoea. emotional lability. fever. gastrointestinal discomfort. haemorrhage. headache. hearing impairment . hemiparesis. hyperglycaemia. hypersensitivity. increased risk of infection. insomnia. level of consciousness decreased. malaise. memory loss. movement disorders. muscle weakness. nausea. neutropenia. oedema. pain. peripheral neuropathy. radiation injury. seizures. sensation abnormal. skin reactions. speech impairment. stomatitis. taste altered. thrombocytopenia. tremor. urinary disorders. vision disorders. vomiting. weight changes ▶Uncommon Altered smell sensation. anaemia. behaviour disorder. bone marrow disorders. cognitive impairment. condition aggravated. Cushing’s syndrome. depression. diabetes insipidus. ear pain. erectile dysfunction. eye pain. gait abnormal. hallucination. hepatic disorders. hyperacusia. hyperbilirubinaemia. hypertension. hypokalaemia. intracranial haemorrhage. myalgia. myopathy. nasal congestion. nervous system disorder. palpitations. photosensitivity reaction. reactivation of infections. thirst. tinnitus. tongue discolouration. vasodilation ▶Rare or very rare Neoplasms. respiratory disorders. secondary malignancy. severe cutaneous adverse reactions (SCARs)
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Manufacturer advises adequate contraception during treatment. Men should avoid fathering a child during and for at least 6 months after treatment. See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Avoid (teratogenic and embryotoxic in animal studies). See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Discontinue breast-feeding.
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Manufacturer advises caution in severe impairment (no information available).
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Manufacturer advises caution—no information available.
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▶Monitor liver function before treatment initiation, after each treatment cycle and midway through 42-day treatment cycles—consider the balance of benefits and risks of treatment if results are abnormal at any point (fatal liver injury reported). ▶Monitor for myelodysplastic syndrome. Immune system and malignant disease ▶Monitor for secondary malignancies.
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Extracted information for Temozolomide only.
There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension Capsule CAUTIONARY AND ADVISORY LABELS 23, 25 ▶Temozolomide (Non-proprietary) Temozolomide 5 mg Temozolomide 5mg capsules | 5 capsule P £16.00 | 5 capsule P £10.06 (Hospital only) Temozolomide 20 mg Temozolomide 20mg capsules | 5 capsule P £65.00 | 5 capsule P £40.23 (Hospital only) Temozolomide 100 mg Temozolomide 100mg capsules | 5 capsule P £325.00 | 5 capsule P £201.18 (Hospital only) Temozolomide 140 mg Temozolomide 140mg capsules | 5 capsule P £465.00 | 5 capsule P £296.47 (Hospital only) Temozolomide 180 mg Temozolomide 180mg capsules | 5 capsule P £586.00 | 5 capsule P £381.18 (Hospital only) Temozolomide 250 mg Temozolomide 250mg capsules | 5 capsule P £814.00 | 5 capsule P £529.42 (Hospital only) ▶Temodal (Merck Sharp & Dohme Ltd) Temozolomide 5 mg Temodal 5mg capsules | 5 capsule P £10.59 (Hospital only) Temozolomide 20 mg Temodal 20mg capsules | 5 capsule P £42.35 (Hospital only) Temozolomide 100 mg Temodal 100mg capsules | 5 capsule P £211.77 (Hospital only) Temozolomide 140 mg Temodal 140mg capsules | 5 capsule P £296.48 (Hospital only) Temozolomide 180 mg Temodal 180mg capsules | 5 capsule P £381.19 (Hospital only) Temozolomide 250 mg Temodal 250mg capsules | 5 capsule P £529.43 (Hospital only)
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Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
(consult product literature)
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 971