Names and pronunciation
(tye-ni′da-zole) Tindamax
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Individual generic drug information
Extracted information for tinidazole only.
(tye-ni′da-zole) Tindamax
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Func. class.: Antiprotozoal
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Chem. class.: Nitroimidazole derivative
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ACTION: Interferes with DNA/RNA synthesis in protozoa
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USES: Amebiasis, giardiasis, tricho- moniasis
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Unlabeled uses: Helicobacter pylori, prophylaxis against STDs following sexual assault, urethritis, nongonococcal
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Extracted information for tinidazole only.
CONTRAINDICATIONS: Preg- nancy, breastfeeding; hypersensitivity to this product or nitroimidazole derivative Precautions: Children, geriatric patients, hepatic disease, CNS depression, blood dyscrasias, candidiasis, seizures, viral infection, alcoholism, pregnancy
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Black Box Warning: Secondary malignancy Black Box Warning: Secondary malig- nancy: avoid unnecessary use • Signs of infection, anemia • Bowel pattern before, during treatment • Pregnancy/breastfeeding: contrain dicated during first trimester; do not breastfeed
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SIDE EFFECTS CNS: Dizziness, headache, seizures, peripheral neuropathy, malaise, fatigue GI: Nausea, vomiting, anorexia, increased AST/ALT, constipation, abdominal pain, indigestion, altered taste HEMA: Leukopenia, neutropenia INTEG: Pruritus, urticaria, rash, oral candidiasis SYST: Angioedema, cramping
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INTERACTIONS • Do not use within 2 wk of disulfiram Increase: tinidazole action—CYP3A4 inhibitors (cimetidine, ketoconazole): increased action of tinidazole Increase: action of anticoagulants, cyclo- SPORINE, tacrolimus, fluorouracil, hydantoins, lithium Decrease: tinidazole action—CYP3A4 inducers (PHENobarbital, rifampin, phe- nytoin); cholestyramine, oxytetracycline: decreased action of tinidazole Drug/Herb Increase or decrease: tinidazole level— St. John’s wort Drug/Lab Test Increase: triglycerides, LDH, AST/ALT, glucose Decrease: WBCs
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Extracted information for tinidazole only.
DOSAGE AND ROUTES Intestinal amebiasis/amebic involvement of the liver • Adult: PO 2 g daily × 3 days • Child ≥3 yr/adolescent: PO 50 mg/kg/ day × 3 days, max 2 g/day Giardiasis • Adult: PO 2 g as a single dose • Child ≥3 yr: PO 50 mg/kg as a single T dose, max 2 g Trichomoniasis • Adult: PO 2 g as a single dose Bacterial vaginosis • Adult (nonpregnant woman): PO 2 g/ day × 2 days with food or 1 g/day × 5 days with food
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Available forms: Tabs 250, 500 mg
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Administer: • Tabs can be crushed and mixed with artificial cherry syrup for children • With food to increase plasma concen- trations, minimize epigastric distress and other GI effects
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Extracted information for tinidazole only.
Assess: • Giardiasis: obtain 3 stool samples several days apart beginning q3-4wk after treatment • Amebic liver abscess: monitor CBC, ESR, amebic gel diffusion test, ultrasound; also total and differential leukocyte count
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Evaluate: • Therapeutic response: decrease in infection as evidenced by negative cul- ture
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: • To take with food to increase plasma concentrations, minimize epigastric dis- tress and other GI effects; not to use alco- holic beverages during or for 3 days after treatment • Trichomoniasis: that all partners should be notified and treated at the same time • To avoid alcohol; may cause disulfiram reaction • To avoid doing hazardous activities until reaction is known • That product causes unpleasant taste • Not to use OTC, Rx, or herbal products unless approved by prescriber See Appendix B
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Extracted information for tinidazole only.
PHARMACOKINETICS Peak 11⁄2 hr; metabolized extensively in liver; excreted unchanged (20%-25%) in urine, (12%) feces; half-life 12-14 hr; crosses blood-brain barrier
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Filter the extracted dose blocks for this individual drug.
Intestinal amebiasis/amebic involvement of the liver
• Adult: PO 2 g daily × 3 days
Candidate age grouping · source page 1295
Intestinal amebiasis/amebic involvement of the liver
• Adult: PO 2 g as a single dose
Candidate age grouping · source page 1295
Intestinal amebiasis/amebic involvement of the liver
• Adult: PO 2 g as a single dose Bacterial vaginosis
Candidate age grouping · source page 1295
Intestinal amebiasis/amebic involvement of the liver
• Adult (nonpregnant woman): PO 2 g/ day × 2 days with food or 1 g/day × 5 days with food
Candidate age grouping · source page 1295