Therapeutic Action
Antifibrinolytic
Source page 497
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Individual generic drug information
Extracted information for TRANEXAMIC acid only.
Antifibrinolytic
Source page 497
Postpartum haemorrhage Heavy abnormal uterine bleeding unrelated to pregnancy Trauma-associated haemorrhage
Source page 497
Extracted information for TRANEXAMIC acid only.
Do not administer to patients with (or with history of) venous or arterial thromboembolic disorders, severe renal impairment, history of seizures. Reduce dosage in patients with mild to moderate renal impairment (risk of accumulation). May cause: gastrointestinal disturbances, hypotension and malaise if injected rapidly (rate > 1 ml/minute), seizures with high doses, visual disturbances, allergic reactions. Avoid combination with drugs that increase the risk of thromboembolism (e.g. oestrogenes). Pregnancy: this drug is not indicated in the event of bleeding during pregnancy. Breast-feeding: no contra-indication
Source page 498
Extracted information for TRANEXAMIC acid only.
500 mg in 5 ml ampoule (100 mg/ml) for slow IV injection or infusion in 0.9% sodium chloride or 5% glucose DO NOT ADMINISTER BY IM ROUTE.
Source page 497
Postpartum haemorrhage Adolescent under 15 years: 15 mg/kg (max. 1 g) Adult: 1 g Administer the dose over 15 minutes, in the first litre used for fluid resuscitation or in a bag of 100 ml of 0.9% sodium chloride, within 3 hours of delivery. If haemorrhage persists 15 minutes after the end of first dose or restarts within 24 hours, administer a second dose in 100 ml of 0.9% sodium chloride over 15 minutes (max. total dose 2 g). Heavy abnormal uterine bleeding unrelated to pregnancy Adolescent and adult: 10 mg/kg every 8 hours until bleeding is reduced (max. 600 mg/dose) then, change to oral route. Trauma-associated haemorrhage Child: 15 mg/kg (max. 1 g) Adult: 1 g Administer the dose over 10 minutes, in 5 ml/kg of 0.9% sodium chloride in children less than 20 kg and in 100 ml of 0.9% sodium chloride in children 20 kg and over and adults, within 3 hours of injury. Then, administer a second dose by continuous IV infusion over 8 hours.
Source page 497
Extracted information for TRANEXAMIC acid only.
Do not mix with benzylpenicillin (incompatibility). Tranexamic acid can also be administered undiluted or diluted in smaller volumes of 0.9% sodium chloride (e.g. 10 ml) in case of fluid restriction (max. 100 mg/minute or 1 ml/minute).
Source page 498
– Below 25 °C
Source page 498
Filter the extracted dose blocks for this individual drug.
15 mg/kg (max. 1 g)
Candidate age grouping · source page 497
10 mg/kg every 8 hours until bleeding is reduced (max. 600 mg/dose) then, change to oral route.
Candidate age grouping · source page 497