Individual generic drug information
Extracted information for Tretinoin only.
Induction of remission in acute promyelocytic leukaemia (used in previously untreated patients as well as in those who have relapsed after standard chemotherapy or who are refractory to it) ▶BY MOUTH ▶Adult: 45 mg/m2 daily in 2 divided doses maximum duration of treatment is 90 days, consult product literature for details of concomitant chemotherapy
Source page 1012
History of depression (risk of neuropsychiatric reactions). increased risk of thromboembolism during first month of treatment
Source page 1013
Tretinoin is the acid form of vitamin A.
Source page 1013
Extracted information for Tretinoin only.
MHRA/CHM ADVICE: ORAL RETINOID MEDICINES: REVISED AND SIMPLIFIED PREGNANCY PREVENTION EDUCATIONAL MATERIALS FOR HEALTHCARE PROFESSIONALS AND WOMEN (JUNE 2019) Materials to support the Pregnancy Prevention Programme in women and girls of childbearing potential taking oral acitretin, alitretinoin, or isotretinoin have been updated. Oral tretinoin and bexarotene do not have a Pregnancy Prevention Programme in light of their oncology indication and specialist care setting. However, healthcare professionals are advised that these medicines are extremely teratogenic and product information should be consulted for contraceptive and pregnancy testing requirements when used in females of childbearing potential. Neuropsychiatric reactions have been reported in patients taking oral retinoids. Healthcare professionals are advised to monitor patients for signs of depression or suicidal ideation and refer for appropriate treatment, if necessary; particular care is needed in those with a history of depression. Patients should be advised to speak to their doctor if they experience any changes in mood or behaviour, and encouraged to ask family and friends to look out for any change in mood.
Source pages 1012, 1013
→Appendix 1: retinoids
Source page 1013
▶Common or very common Abdominal pain. alopecia. anxiety. appetite decreased. arrhythmia. asthma. bone pain. cheilitis. chest pain. chills. confusion. constipation . depression. diarrhoea. dizziness. dry mouth. flushing. headache. hearing impairment. hyperhidrosis. insomnia. intracranial pressure increased. malaise. nasal dryness. nausea. pancreatitis. paraesthesia. respiratory disorders. skin reactions. visual impairment. vomiting ▶Frequency not known Embolism and thrombosis. erythema nodosum. genital ulceration. hepatotoxicity. hypercalcaemia. increased leucocytes. myocardial infarction. myositis. necrotising fasciitis. QT interval prolongation. stroke. thrombocytosis. vasculitis SIDE-EFFECTS, FURTHER INFORMATION Retinoic acid syndrome Fever, dyspnoea, acute respiratory distress, pulmonary infiltrates, pleural effusion, hyperleucocytosis, hypotension, oedema, weight gain, hepatic, renal and multi-organ failure requires immediate treatment— consult product literature.
Source page 1013
Effective contraception must be used for at least 1 month before oral treatment, during treatment and for at least 1 month after stopping (oral progestogen-only contraceptives not considered effective).
Source page 1013
Teratogenic. See Pregnancy and reproductive function in Cytotoxic drugs p. 938.
Source page 1013
Avoid (discontinue breast-feeding).
Source page 1013
Manufacturer advises caution. Dose adjustments Manufacturer advises dose reduction to 25 mg/m2.
Source page 1013
Dose adjustments Reduce dose to 25 mg/m2.
Source page 1013
Monitor haematological and coagulation profile, liver function, serum calcium and plasma lipids before and during treatment.
Source page 1013
Extracted information for Tretinoin only.
There can be variation in the licensing of different medicines containing the same drug. Capsule CAUTIONARY AND ADVISORY LABELS 21, 25 ▶Tretinoin (Non-proprietary) Tretinoin 10 mg Tretinoin 10mg capsules | 100 capsule P £300.00–£315.00 DT = £300.00 3.1 Cytotoxic drug-induced side effects ANTIDOTES AND CHELATORS › IRON CHELATORS
Source page 1013
Extracted information for Tretinoin only.
Risk of neuropsychiatric reactions The MHRA advises patients and carers to seek medical attention if changes in mood or behaviour occur.
Source page 1013
Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
45 mg/m2 daily in 2 divided doses maximum
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 1012
