Individual generic drug information

trifluoperazine

Reference monograph

Part of registered formulation

TRIFLUOPERAZINE

Reference record: Trifluoperazine
Source: BNF 80 (2020–2021)
Printed source pages: 430, 431
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Trifluoperazine only.

Indications And Dose

Schizophrenia and other psychoses | Short-term adjunctive management of psychomotor agitation, excitement, and violent or dangerously impulsive behaviour ▶BY MOUTH ▶Adult: Initially 5 mg twice daily, daily dose may be increased by 5 mg after 1 week. If necessary, dose may be further increased in steps of 5 mg at intervals of 3 days. When satisfactory control has been achieved, reduce gradually until an effective maintenance level has been established ▶Elderly: Initially up to 2.5 mg twice daily, daily dose may be increased by 5 mg after 1 week. If necessary, dose may be further increased in steps of 5 mg at intervals of 3 days. When satisfactory control has been achieved, reduce gradually until an effective maintenance level has been established Short-term adjunctive management of severe anxiety ▶BY MOUTH ▶Adult: 2–4 mg daily in divided doses, increased if necessary to 6 mg daily ▶Elderly: Up to 2 mg daily in divided doses, increased if necessary to 6 mg daily Severe nausea and vomiting ▶BY MOUTH ▶Adult: 2–4 mg daily in divided doses; maximum 6 mg per day

Source page 430

Contra Indications

CNS depression. comatose states. phaeochromocytoma

Source page 430

Safety

Extracted information for Trifluoperazine only.

Interactions

→Appendix 1: phenothiazines

Source page 430

Side Effects

Alertness decreased. anxiety. appetite decreased. blood disorder. cardiac arrest. confusion. fatigue. hyperpyrexia. jaundice cholestatic. lens opacity. muscle weakness. oedema. pancytopenia. photosensitivity reaction. postural hypotension (dose- related). skin reactions. thrombocytopenia. urinary hesitation. vision blurred. withdrawal syndrome SIDE-EFFECTS, FURTHER INFORMATION Extrapyramidal symptoms are more frequent at doses exceeding 6mg daily. Acute dystonias are more common with potent ﬁrst generation antipsychotics. The risk is increased in men, young adults, children, antipsychotic-naïve patients, rapid dose escalation, and abrupt treatment discontinuation.

Source page 430

Hepatic Impairment

Manufacturer advises avoid.

Source page 430

Renal Impairment

Dose adjustments Start with small doses in severe renal impairment because of increased cerebral sensitivity.

Source page 430

Monitoring Requirements

Triﬂuoperazine does not affect blood pressure to the same extent as other antipsychotic drugs and so blood pressure monitoring is not mandatory for this drug.

Source pages 430, 431

Dose and formulations

Extracted information for Trifluoperazine only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Oral solution CAUTIONARY AND ADVISORY LABELS 2 ▶Trifluoperazine (Non-proprietary) Trifluoperazine (as Trifluoperazine hydrochloride) 200 microgram per 1 ml Trifluoperazine 1mg/5ml oral solution sugar free sugar-free | 200 ml P £125.00 DT = £125.00 Trifluoperazine (as Trifluoperazine hydrochloride) 1 mg per 1 ml Trifluoperazine 5mg/5ml oral solution sugar free sugar-free | 150 ml P £30.00 DT = £29.25 Tablet CAUTIONARY AND ADVISORY LABELS 2 ▶Trifluoperazine (Non-proprietary) Trifluoperazine (as Trifluoperazine hydrochloride) 1 mg Trifluoperazine 1mg tablets | 112 tablet P £59.12–£99.80 DT = £59.12 Trifluoperazine (as Trifluoperazine hydrochloride) 5 mg Trifluoperazine 5mg tablets | 112 tablet P £134.89– £165.00 DT = £134.89 eiiii F 401

Source page 431

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 5 mg twice daily, daily dose may be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 430

Adults

First line only; read the complete Indications and dose section above.

2–4 mg daily in divided doses, increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 430

Adults

First line only; read the complete Indications and dose section above.

2–4 mg daily in divided doses; maximum 6 mg

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 430

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

trifluoperazine

Reference monograph

Part of registered formulation

TRIFLUOPERAZINE

Reference record: Trifluoperazine
Source: BNF 80 (2020–2021)
Printed source pages: 430, 431
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Trifluoperazine only.

Indications And Dose

Source page 430

Contra Indications

CNS depression. comatose states. phaeochromocytoma

Source page 430

Safety

Extracted information for Trifluoperazine only.

Interactions

→Appendix 1: phenothiazines

Source page 430

Side Effects

Source page 430

Hepatic Impairment

Manufacturer advises avoid.

Source page 430

Renal Impairment

Dose adjustments Start with small doses in severe renal impairment because of increased cerebral sensitivity.

Source page 430

Monitoring Requirements

Triﬂuoperazine does not affect blood pressure to the same extent as other antipsychotic drugs and so blood pressure monitoring is not mandatory for this drug.

Source pages 430, 431

Dose and formulations

Extracted information for Trifluoperazine only.

Medicinal Forms

Source page 431

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 5 mg twice daily, daily dose may be

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 430

Adults

First line only; read the complete Indications and dose section above.

2–4 mg daily in divided doses, increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 430

Adults

First line only; read the complete Indications and dose section above.

2–4 mg daily in divided doses; maximum 6 mg

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 430

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.