Indications And Dose
Respiratory-tract infections ▶BY MOUTH ▶Child 4–5 weeks: 4 mg/kg twice daily (max. per dose 200 mg) ▶Child 6 weeks–5 months: 4 mg/kg twice daily (max. per dose 200 mg), alternatively 25 mg twice daily ▶Child 6 months–5 years: 4 mg/kg twice daily (max. per dose 200 mg), alternatively 50 mg twice daily ▶Child 6–11 years: 4 mg/kg twice daily (max. per dose 200 mg), alternatively 100 mg twice daily ▶Child 12–17 years: 200 mg twice daily ▶Adult: 200 mg twice daily Prophylaxis of recurrent urinary-tract infection ▶BY MOUTH ▶Child 4–5 weeks: 2 mg/kg once daily, dose to be taken at night ▶Child 6 weeks–5 months: 2 mg/kg once daily, alternatively 12.5 mg once daily, dose to be taken at night ▶Child 6 months–5 years: 2 mg/kg once daily (max. per dose 100 mg), alternatively 25 mg once daily, dose to be taken at night ▶Child 6–11 years: 2 mg/kg once daily (max. per dose 100 mg), alternatively 50 mg once daily, dose to be taken at night ▶Child 12–15 years: 100 mg once daily, dose to be taken at night ▶Child 16–17 years: 100 mg once daily, dose to be taken at night, alternatively 200 mg for 1 dose, following exposure to a trigger ▶Adult: 100 mg once daily, dose to be taken at night, alternatively 200 mg for 1 dose, following exposure to a trigger Treatment of mild to moderate Pneumocystis jirovecii (Pneumocystis carinii) pneumonia in patients who cannot tolerate co-trimoxazole (in combination with dapsone) ▶BY MOUTH ▶Child: 5 mg/kg every 6–8 hours ▶Adult: 5 mg/kg every 6–8 hours Acne resistant to other antibacterials ▶BY MOUTH ▶Adult: 300 mg twice daily Shigellosis | Invasive salmonella infection ▶BY MOUTH ▶Adult: (consult product literature) Acute diverticulitis [in combination with metronidazole] ▶BY MOUTH Infection ▶Adult: 200 mg twice daily for 5 days then review Acute prostatitis ▶BY MOUTH ▶Adult: 200 mg twice daily for 14 or 28 days based on clinical assessment Acute pyelonephritis ▶BY MOUTH ▶Child 16–17 years: 200 mg twice daily for 14 days ▶Adult: 200 mg twice daily for 14 days Urinary-tract infection (catheter-associated) ▶BY MOUTH ▶Child 3–5 months: 4 mg/kg twice daily (max. per dose 200 mg) for 7–10 days, alternatively 25 mg twice daily for 7–10 days ▶Child 6 months–5 years: 4 mg/kg twice daily (max. per dose 200 mg) for 7–10 days, alternatively 50 mg twice daily for 7–10 days ▶Child 6–11 years: 4 mg/kg twice daily (max. per dose 200 mg) for 7–10 days, alternatively 100 mg twice daily for 7–10 days ▶Child 12–15 years: 200 mg twice daily for 7–10 days ▶Child 16–17 years: 200 mg twice daily for 7 days (14 days if upper urinary-tract symptoms are present) ▶Adult: 200 mg twice daily for 7 days (14 days if upper urinary-tract symptoms are present) Lower urinary-tract infection ▶BY MOUTH ▶Child 4–5 weeks: 4 mg/kg twice daily (max. per dose 200 mg) ▶Child 6 weeks–2 months: 4 mg/kg twice daily (max. per dose 200 mg), alternatively 25 mg twice daily ▶Child 3–5 months: 4 mg/kg twice daily (max. per dose 200 mg) for 3 days, alternatively 25 mg twice daily for 3 days ▶Child 6 months–5 years: 4 mg/kg twice daily (max. per dose 200 mg) for 3 days, alternatively 50 mg twice daily for 3 days ▶Child 6–11 years: 4 mg/kg twice daily (max. per dose 200 mg) for 3 days, alternatively 100 mg twice daily for 3 days ▶Child 12–15 years: 200 mg twice daily for 3 days ▶Child 16–17 years: 200 mg twice daily for 3 days (7 days in males) ▶Adult: 200 mg twice daily for 3 days (7 days in males) l UNLICENSED USE g Trimethoprim can be given as a single dose for the prophylaxis of recurrent urinary-tract infection following exposure to a trigger, h but this dosing regimen is not licensed. Not licensed for treatment of pneumocystis pneumonia. Not licensed for treatment of acne resistant to other antibacterials. ▶In children Not licensed for use in children under 6 months for the prophylaxis of recurrent urinary-tract infection. Not licensed for use in children under 6 weeks.
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