Drug reference

Acenocoumarol

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 172

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Prophylaxis of embolisation in rheumatic heart disease and atrial fibrillation | Prophylaxis after insertion of prosthetic heart valve| Prophylaxis and treatment of venous thrombosis and pulmonary embolism | Transient ischaemic attacks ▶BY MOUTH ▶Adult: Initially 2–4 mg once daily for 2 days, alternatively initially 6 mg on day 1, then 4 mg on day 2; maintenance 1–8 mg daily, adjusted according to response, dose to be taken at the same time each day, lower doses may be required in patients over 65 years, severe heart failure with hepatic congestion, and malnutrition

PDF page 172

Cautions

Patients over 65 years

PDF page 172

Safety

Interactions

→Appendix 1: coumarins

PDF page 172

Side Effects

▶Rare or very rare Appetite decreased. liver injury. skin necrosis haemorrhagic (increased risk in patients with protein C or protein S deﬁciency). vasculitis

PDF page 172

Breast Feeding

Risk of haemorrhage; increased by vitamin K deﬁciency—manufacturer recommends prophylactic vitamin K for the infant (consult product literature).

PDF page 172

Hepatic Impairment

Dose adjustments Manufacturer advises consider dose reduction in mild to moderate impairment.

PDF page 172

Renal Impairment

Caution in mild to moderate impairment. Avoid in severe impairment.

PDF page 172

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 10 ▶Sinthrome (Norgine Pharmaceuticals Ltd) Acenocoumarol 1 mg Sinthrome 1mg tablets | 100 tablet P £4.62 DT = £4.62 eiiii F 149

PDF page 172

Clinical care

Patient And Carer Advice

Anticoagulant card to be provided.

PDF page 172

Dose text by age group

Adult

Initially 2–4 mg once daily for 2 days,

First-line fragment. Read the complete Indications and Dose section above.

PDF page 172

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Acenocoumarol

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 172

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 172

Cautions

Patients over 65 years

PDF page 172

Safety

Interactions

→Appendix 1: coumarins

PDF page 172

Side Effects

▶Rare or very rare Appetite decreased. liver injury. skin necrosis haemorrhagic (increased risk in patients with protein C or protein S deﬁciency). vasculitis

PDF page 172

Breast Feeding

Risk of haemorrhage; increased by vitamin K deﬁciency—manufacturer recommends prophylactic vitamin K for the infant (consult product literature).

PDF page 172

Hepatic Impairment

Dose adjustments Manufacturer advises consider dose reduction in mild to moderate impairment.

PDF page 172

Renal Impairment

Caution in mild to moderate impairment. Avoid in severe impairment.

PDF page 172

Dose and formulations

Medicinal Forms

PDF page 172

Clinical care

Patient And Carer Advice

Anticoagulant card to be provided.

PDF page 172

Dose text by age group

Adult

Initially 2–4 mg once daily for 2 days,

First-line fragment. Read the complete Indications and Dose section above.

PDF page 172

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.