Names and pronunciation
(a-set-a-zole′a-mide) Diamox
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Drug reference
(a-set-a-zole′a-mide) Diamox
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Func. class.: Diuretic, carbonic anhydrase inhibitor, antiglaucoma agent, antiepileptic
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Chem. class.: Sulfonamide derivative
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USES: Open-angle glaucoma, angle- closure glaucoma (preoperatively, if surgery delayed), mixed, tonic-clonic, myoclonic, refractory seizures, epilepsy (petit mal, grand mal, absence), edema in HF, product- induced edema, acute altitude sickness
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CONTRAINDICATIONS: Hyper- sensitivity to sulfonamides, severe renal/ hepatic disease, electrolyte imbalances (hyponatremia, hypokalemia), hyper- chloremic acidosis, Addison’s disease, long-term use for closed-angle glau- coma, adrenocortical insufficiency, meta- bolic acidosis, acidemia, anuria
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DOSAGE AND ROUTES Angle-closure glaucoma • Adult: PO/IV 250 mg q4hr or 250 mg bid for short-term therapy Chronic open-angle glaucoma • Adult: PO/IV 250 mg 1-4 times per day or 500 mg EXTENDED RELEASE bid, max 1 g/day • Child (unlabeled): PO 8-30 mg/kg/day A in divided doses tid or qid, or 300-900 mg/m2/day, max 1 g/day; IV 5-10 mg q6hr, max 1 g/day Edema in heart failure, drug- induced edema • Adult: PO/IV 250-375 mg/day • Child (unlabeled): PO/IV 5 mg/kg/day or 150 mg/m2 in AM Adjunct for epilepsy and myoclonic, refractory, generalized tonic-clonic, absence or mixed seizures • Adult: PO/IV 8-30 mg/kg/day in 1-4 divided doses, usual range 375-1000 mg/ day; EXTENDED RELEASE not recom- mended with seizures Altitude sickness • Adult: PO 250 mg twice daily starting the day before ascent and continuing for 2 to 3 days after reaching the target alti- tude or until descent is initiated Renal dose • Adult: PO/IV CCr 50-80 mL/min give dose ≥q6hr regular release or IV; CCr 10- 50 mL/min give dose q12hr; CCr <10 mL/min, avoid use See Appendix B
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• Child (unlabeled): PO 8-30 mg/kg/day A in divided doses tid or qid, or 300-900 mg/m2/day, max 1 g/day; IV 5-10 mg q6hr, max 1 g/day Edema in heart failure, drug- induced edema
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• Child (unlabeled): PO/IV 5 mg/kg/day or 150 mg/m2 in AM Adjunct for epilepsy and myoclonic, refractory, generalized tonic-clonic, absence or mixed seizures
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