Drug reference
Chronic hepatitis B infection with either compensated liver disease with evidence of viral replication, and histologically documented active liver inflammation and fibrosis, when other treatment not appropriate or decompensated liver disease in combination with another antiviral for chronic hepatitis B that has no cross-resistance to adefovir ▶BY MOUTH ▶Adult: 10 mg once daily
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Elderly CAUTIONS, FURTHER INFORMATION Discontinue if deterioration in liver function, hepatic steatosis, progressive hepatomegaly or unexplained lactic acidosis.
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→Appendix 1: adefovir
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▶Common or very common Asthenia. diarrhoea. flatulence. gastrointestinal discomfort. headache. nausea. renal impairment. skin reactions. vomiting ▶Frequency not known Bone fracture. bone pain. hypophosphataemia. myopathy. nephrotoxicity. osteomalacia. pancreatitis. proximal renal tubulopathy
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Effective contraception required during treatment.
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Toxicity in animal studies—manufacturer advises use only if potential benefit outweighs risk.
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Manufacturer advises avoid—no information available.
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No information available if eGFR less than 10 mL/minute/1.73 m2. Dose adjustments 10 mg every 48 hours if eGFR 30–50 mL/minute/1.73 m2; 10 mg every 72 hours if eGFR 10–30 mL/minute/1.73 m2. Monitoring Monitor renal function more frequently in patients with renal impairment.
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▶Monitor liver function tests every 3 months, and viral markers for hepatitis B every 3–6 months during treatment (continue monitoring for at least 1 year after discontinuation—recurrent hepatitis may occur on discontinuation). ▶Monitor renal function before treatment then every 3 months, more frequently in patients receiving Infection nephrotoxic drugs.
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There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Hepsera (Gilead Sciences International Ltd) Adefovir dipivoxil 10 mg Hepsera 10mg tablets | 30 tablet P £252.22 DT = £252.22 IMMUNOSTIMULANTS › INTERFERONS
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10 mg once daily
First-line fragment. Read the complete Indications and Dose section above.
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