Drug Action
Acts on both alpha and beta receptors and increases both heart rate and contractility (beta1 effects); it can cause peripheral vasodilation (a beta2 effect) or vasoconstriction (an alpha effect).
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Drug reference
Acts on both alpha and beta receptors and increases both heart rate and contractility (beta1 effects); it can cause peripheral vasodilation (a beta2 effect) or vasoconstriction (an alpha effect).
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Priapism associated with alprostadil, if aspiration and lavage of corpora are unsuccessful (alternative to phenylephrine or metaraminol) ▶BY INTRACAVERNOSAL INJECTION ▶Adult: 10–20 micrograms every 5–10 minutes, using a 20 microgram/mL solution, Important: if suitable strength of adrenaline not available may be specially prepared by diluting 0.1 mL of the adrenaline 1 in 1000 (1 mg/mL) injection to 5 mL with sodium chloride 0.9%, continuously monitor blood pressure and pulse; maximum 100 micrograms per course l UNLICENSED USE The use of adrenaline for the treatment of priapism is an unlicensed indication.
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Arteriosclerosis. arrhythmias. cerebrovascular disease. cor pulmonale. diabetes mellitus. elderly. hypercalcaemia. hyperreflexia. hypertension. hyperthyroidism. hypokalaemia. ischaemic heart disease. obstructive cardiomyopathy. occlusive vascular disease. organic brain damage. phaeochromocytoma. prostate disorders. psychoneurosis. severe angina. susceptibility to angle-closure glaucoma CAUTIONS, FURTHER INFORMATION Cautions listed are only for non-life-threatening situations.
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→Appendix 1: sympathomimetics, vasoconstrictor
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▶Rare or very rare Cardiomyopathy ▶Frequency not known Angina pectoris. angle closure glaucoma. anxiety. appetite decreased. arrhythmias. asthenia. CNS haemorrhage. confusion. dizziness. dry mouth. dyspnoea. headache. hepatic necrosis. hyperglycaemia. hyperhidrosis. hypersalivation. hypertension (increased risk of cerebral haemorrhage). hypokalaemia. injection site necrosis. insomnia. intestinal necrosis. metabolic acidosis. mydriasis. myocardial infarction. nausea. pallor. palpitations. peripheral coldness. psychosis. pulmonary oedema (on excessive dosage or extreme sensitivity). renal necrosis. soft tissue necrosis. tremor. urinary disorders. vomiting
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Manufacturers advise use with caution in severe impairment.
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Monitor blood pressure and ECG.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: solution for injection Solution for injection EXCIPIENTS: May contain Sulfites ▶Adrenaline/epinephrine (Non-proprietary) Adrenaline 100 microgram per 1 ml Adrenaline (base) 100micrograms/1ml (1 in 10,000) dilute solution for injection ampoules | 10 ampoule P £88.18 Adrenaline (base) 1mg/10ml (1 in 10,000) dilute solution for injection pre-filled syringes | 1 pre-filled disposable injection P £6.87 | 1 pre-filled disposable injection P £18.00 (Hospital only) | 10 pre- filled disposable injection P £180.00 (Hospital only) Adrenaline (as Adrenaline acid tartrate) 100 microgram per 1 ml Adrenaline (base) 1mg/10ml (1 in 10,000) dilute solution for injection ampoules | 10 ampoule P £102.19 Adrenaline (base) 500micrograms/5ml (1 in 10,000) dilute solution for injection ampoules | 10 ampoule P £93.94 Adrenaline 1 mg per 1 ml Adrenaline (base) 10mg/10ml (1 in 1,000) solution for injection ampoules | 10 ampoule P £106.02 Adrenaline (base) for anaphylaxis 1mg/1ml (1 in 1,000) solution for injection pre-filled syringes | 1 pre-filled disposable injection P £11.88 DT = £11.88 Adrenaline (base) 1mg/1ml (1 in 1,000) solution for injection pre-filled syringes | 1 pre-filled disposable injection P £11.88 DT = £11.88 Adrenaline (as Adrenaline acid tartrate) 1 mg per 1 ml Adrenaline (base) 5mg/5ml (1 in 1,000) solution for injection ampoules | 10 ampoule P £108.09 Adrenaline (base) 500micrograms/0.5ml (1 in 1,000) solution for injection ampoules | 10 ampoule P £88.63 DT = £88.63 Adrenaline (base) 1mg/1ml (1 in 1,000) solution for injection ampoules | 10 ampoule P £6.00–£11.01 DT = £9.98
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10–20 micrograms every 5–10 minutes, using a
First-line fragment. Read the complete Indications and Dose section above.
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