Names and pronunciation
(a-fat′i-nib) Gilotrif
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Drug reference
(a-fat′i-nib) Gilotrif
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Func. class.: Antineoplastic biologic response modifiers
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USES: Treatment of non–small-cell lung cancer whose tumors have epidermal growth factor receptor exon 19 deletions or 21 substitution mutations
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CONTRAINDICATIONS: Preg- nancy, hypersensitivity
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DOSAGE AND ROUTES • Adult: PO 40 mg daily until disease progression or unacceptable toxicity Dose adjustments for toxicities: • Hepatotoxicity: Hold in worsening liver function; when toxicity resolves to grade 1 or less, resume at a reduced dose (10 mg/ day less than the dose causing hepatotoxic- ity); permanently discontinue for severe drug-induced hepatic impairment or if hep- atotoxicity persists at a dose of 20 mg/day • Grade 2 or higher renal toxicity (CCr >1.5 × ULN): Hold until the toxicity re- solves to grade 1 or less (CCr <1.5 × ULN), then resume at a reduced dose (10 mg/day less than the dose causing nephrotoxicity); permanently discontinue if nephrotoxicity persists at a dose of 20 mg/day
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• Adult: PO 40 mg daily until disease progression or unacceptable toxicity Dose adjustments for toxicities:
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