Drug reference

Albumin solution

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1131, 1132

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Acute or sub-acute loss of plasma volume e.g. in burns, pancreatitis, trauma, and complications of surgery (with isotonic solutions) | Plasma exchange (with isotonic solutions) | Severe hypoalbuminaemia associated with low plasma volume and generalised oedema where salt and water restriction with plasma volume expansion are required (with concentrated solutions 20%) | Paracentesis of large volume ascites associated with portal hypertension (with concentrated solutions 20%) ▶BY INTRAVENOUS INFUSION ▶Adult: (consult product literature)

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Cautions

Correct dehydration when administering concentrated solution. history of cardiovascular disease. increased capillary permeability. risk of haemodilution (e.g. severe anaemia or haemorrhagic disorders). risk of hypervolaemia (e.g. oesophageal varices or pulmonary oedema). vaccination against hepatitis A and hepatitis B may be required CAUTIONS, FURTHER INFORMATION ▶Volume status Manufacturer advises adjust dose and rate of infusion to avoid ﬂuid overload.

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Prescribing And Dispensing Information

A solution containing protein derived from plasma, serum, or normal placentas; at least 95% of the protein is albumin. The solution may be isotonic (containing 3.5–5% protein) or concentrated (containing 15–25% protein).

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Safety

Side Effects

▶Rare or very rare Fever. ﬂushing. nausea. shock. urticaria

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Monitoring Requirements

Plasma and plasma substitutes are often used in very ill patients whose condition is unstable. Therefore, close monitoring is required and ﬂuid and electrolyte therapy should be adjusted according to the patient’s condition at all times.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Infusion ▶Flexbumin (Baxalta UK Ltd) Albumin solution human 200 gram per 1 litre Flexbumin 20% infusion 100ml bags | 1 bag P s Flexbumin 20% infusion 50ml bags | 1 bag P s Solution for infusion ▶Albunorm (Octapharma Ltd) Albumin solution human 50 mg per 1 ml Albunorm 5% solution for infusion 250ml bottles | 1 bottle P £33.75 Albunorm 5% solution for infusion 100ml bottles | 1 bottle P £13.50 Albunorm 5% solution for infusion 500ml bottles | 1 bottle P £67.50 Albumin solution human 200 mg per 1 ml Albunorm 20% solution for infusion 100ml bottles | 1 bottle P £54.00 Albunorm 20% solution for infusion 50ml bottles | 1 bottle P £27.00 ▶Alburex (CSL Behring UK Ltd) Albumin solution human 50 mg per 1 ml Alburex 5% solution for infusion 500ml vials | 1 vial P £50.00 Albumin solution human 200 mg per 1 ml Alburex 20% solution for infusion 100ml vials | 1 vial P £40.00 ▶Albutein (Grifols UK Ltd) Albumin solution human 50 mg per 1 ml Albutein 5% solution for infusion 500ml vials | 1 vial P s Albutein 5% solution for infusion 250ml vials | 1 vial P s Albumin solution human 200 mg per 1 ml Albutein 20% solution for infusion 100ml vials | 1 vial P s Albutein 20% solution for infusion 50ml vials | 1 vial P s ▶Biotest (Biotest (UK) Ltd) Albumin solution human 50 mg per 1 ml Human Albumin Biotest 5% solution for infusion 250ml vials | 1 vial P s Albumin solution human 200 mg per 1 ml Human Albumin Biotest Blood and nutrition 20% solution for infusion 50ml vials | 1 vial P s Human Albumin Biotest 20% solution for infusion 100ml vials | 1 vial P s ▶Grifols (Grifols UK Ltd) Albumin solution human 50 mg per 1 ml Human albumin Grifols 5% solution for infusion 500ml bottles | 1 bottle P £42.75 Human albumin Grifols 5% solution for infusion 250ml bottles | 1 bottle P £21.38 Albumin solution human 200 mg per 1 ml Human Albumin Grifols 20% solution for infusion 50ml vials | 1 vial P £23.40 Human Albumin Grifols 20% solution for infusion 100ml vials | 1 vial P £46.80 ▶Zenalb (Bio Products Laboratory Ltd) Albumin solution human 45 mg per 1 ml Zenalb 4.5% solution for infusion 250ml bottles | 1 bottle P £27.51 Zenalb 4.5% solution for infusion 500ml bottles | 1 bottle P £55.02 Albumin solution human 200 mg per 1 ml Zenalb 20% solution for infusion 100ml bottles | 1 bottle P £54.00 Zenalb 20% solution for infusion 50ml bottles | 1 bottle P £27.00 PLASMA SUBSTITUTES

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Dose text by age group

Adult

(consult product literature)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1131

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

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Drug reference

Albumin solution

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1131, 1132

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 1131

Cautions

PDF page 1131

Prescribing And Dispensing Information

PDF page 1131

Safety

Side Effects

▶Rare or very rare Fever. ﬂushing. nausea. shock. urticaria

PDF page 1131

Monitoring Requirements

PDF page 1131

Dose and formulations

Medicinal Forms

PDF pages 1131, 1132

Dose text by age group

Adult

(consult product literature)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1131

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.