Indications And Dose
Patients with severe renal impairment requiring vitamin D therapy ▶BY MOUTH, OR BY INTRAVENOUS INJECTION ▶Adult: Initially 1 microgram daily, dose to be adjusted to avoid hypercalcaemia; maintenance 0.25–1 microgram daily ▶Elderly: Initially 500 nanograms daily, dose adjusted to avoid hypercalcaemia; maintenance 0.25–1 microgram daily Hypophosphataemic rickets | Persistent hypocalcaemia due to hypoparathyroidism or pseudohypoparathyroidism ▶BY MOUTH, OR BY INTRAVENOUS INJECTION ▶Child 1 month–11 years: 25–50 nanograms/kg once daily, dose to be adjusted as necessary; maximum 1 microgram per day ▶Child 12–17 years: 1 microgram once daily, dose to be adjusted as necessary Prevention of vitamin D deficiency in renal or cholestatic liver disease ▶BY MOUTH, OR BY INTRAVENOUS INJECTION ▶Child 1 month–11 years (body-weight up to 20 kg): 15–30 nanograms/kg once daily (max. per dose 500 nanograms) ▶Child 1 month–11 years (body-weight 20 kg and above): 250–500 nanograms once daily, dose to be adjusted as necessary ▶Child 12–17 years: 250–500 nanograms once daily, dose to be adjusted as necessary DOSE EQUIVALENCE AND CONVERSION ▶One drop of alfacalcidol 2 microgram/mL oral drops contains approximately 100 nanograms alfacalcidol.
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