Indications And Dose
Spontaneous respiration: analgesia and enhancement of anaesthesia for short procedures ▶BY INTRAVENOUS INJECTION ▶Adult: Initially up to 500 micrograms, dose to be administered over 30 seconds; supplemental doses continued → 250 micrograms Assisted ventilation: analgesia and enhancement of anaesthesia for short procedures ▶BY INTRAVENOUS INJECTION ▶Adult: Initially 30–50 micrograms/kg, supplemental doses 15 micrograms/kg Assisted ventilation: analgesia and enhancement of anaesthesia during maintenance of anaesthesia for longer procedures ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 50–100 micrograms/kg, dose to be administered over 10 minutes or as a bolus, followed by maintenance 30–60 micrograms/kg/hour Assisted ventilation: analgesia and suppression of respiratory activity during intensive care for up to 4 days ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 2 mg/hour, adjusted according to response; usual dose 0.5–10 mg/hour, alternatively initially 5 mg in divided doses, to be administered over 10 minutes; dose used for more rapid initial control, reduce rate of administration if hypotension or bradycardia occur; additional doses of 0.5–1 mg may be Anaesthesia given by intravenous injection during short painful procedures DOSES AT EXTREMES OF BODY-WEIGHT ▶To avoid excessive dosage in obese patients, dose should be calculated on the basis of ideal body-weight.
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