Drug reference
Urticaria | Pruritus ▶BY MOUTH ▶Child 2–4 years: 2.5 mg 3–4 times a day ▶Child 5–11 years: 5 mg 3–4 times a day ▶Child 12–17 years: 10 mg 2–3 times a day, in severe cases up to maximum daily dose has been used; maximum 100 mg per day ▶Adult: 10 mg 2–3 times a day, in severe cases up to maximum daily dose has been used; maximum 100 mg per day ▶Elderly: 10 mg 1–2 times a day
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Epilepsy. hepatic dysfunction. history of narrow angle glaucoma. hypothyroidism. myasthenia gravis. Parkinson’s disease. phaeochromocytoma. prostatic hypertrophy (in adults). renal dysfunction
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Cardiovascular diseases (due to tachycardia- inducing and hypotensive effects of phenothiazines). elderly. exposure to sunlight should be avoided during treatment with high doses. pyloroduodenal obstruction. urinary retention. volume depleted patients who are more susceptible to orthostatic hypotension
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→Appendix 1: antihistamines, sedating
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Agitation. agranulocytosis. amenorrhoea. atrioventricular block. autonomic dysfunction. bile thrombus. consciousness impaired. drug fever. dry mouth . eosinophilia. erectile dysfunction. eye disorder. galactorrhoea. gynaecomastia. hepatic disorders. Respiratory system hyperprolactinaemia. hyperthermia. hypotension. insomnia. leucopenia (on prolonged high dose). movement disorders. muscle rigidity. nasal congestion. neuroleptic malignant syndrome. pallor. parkinsonism. photosensitivity reaction. postural hypotension (more common in the elderly or in volume depletion). QT interval prolongation. respiratory depression. seizure. skin reactions. tardive dyskinesia (more common after long term high doses). tremor. ventricular fibrillation (increased risk with hypokalamia and cardiac disease). ventricular tachycardia (increased risk with hypokalamia and cardiac disease) SIDE-EFFECTS, FURTHER INFORMATION Drowsiness may diminish after a few days. Patients on high dosage may develop photosensitivity and should avoid exposure to direct sunlight. Children and elderly patients are more susceptible to side-effects.
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Most manufacturers of antihistamines advise avoiding their use during pregnancy; however, there is no evidence of teratogenicity. Use in the latter part of the third trimester may cause adverse effects in neonates such as irritability, paradoxical excitability, and tremor.
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Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.
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Manufacturer advises avoid—no information available.
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Avoid.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral solution Oral solution CAUTIONARY AND ADVISORY LABELS 2 ▶Alimemazine tartrate (Non-proprietary) Alimemazine tartrate 1.5 mg per 1 ml Alimemazine 7.5mg/5ml oral solution | 100 ml P £179.58 DT = £179.58 Alimemazine tartrate 6 mg per 1 ml Alimemazine 30mg/5ml oral solution | 100 ml P £243.51 DT = £243.51 Tablet CAUTIONARY AND ADVISORY LABELS 2 ▶Alimemazine tartrate (Non-proprietary) Alimemazine tartrate 10 mg Alimemazine 10mg tablets | 28 tablet P £112.88 DT = £112.88
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Driving and skilled tasks Drowsiness may affect performance of skilled tasks (e.g. cycling or driving); sedating effects enhanced by alcohol.
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2.5 mg 3–4 times a day
First-line fragment. Read the complete Indications and Dose section above.
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5 mg 3–4 times a day
First-line fragment. Read the complete Indications and Dose section above.
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10 mg 2–3 times a day, in severe cases
First-line fragment. Read the complete Indications and Dose section above.
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