Drug reference
Treatment of acute migraine ▶BY MOUTH ▶Adult: 12.5 mg, dose to be taken as soon as possible after onset, followed by 12.5 mg after 2 hours if required, dose to be taken only if migraine recurs (patient not responding to initial dose should not take second dose for same attack); maximum 25 mg per day l UNLICENSED USE Not licensed for use in elderly.
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Coronary vasospasm. ischaemic heart disease. peripheral vascular disease. previous cerebrovascular accident. previous myocardial infarction. previous transient ischaemic attack. Prinzmetal’s angina. severe hypertension. uncontrolled hypertension
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Conditions which predispose to coronary artery disease. elderly
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Caution in patients with sensitivity to sulfonamides.
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→Appendix 1: almotriptan
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▶Common or very common Asthenia. dizziness. drowsiness. nausea. vomiting ▶Uncommon Bone pain. chest pain. diarrhoea. dry mouth. dyspepsia. headache. myalgia. palpitations. paraesthesia . throat tightness. tinnitus ▶Rare or very rare Coronary vasospasm. myocardial infarction. tachycardia ▶Frequency not known Intestinal ischaemia. seizure. vision disorders SIDE-EFFECTS, FURTHER INFORMATION Discontinue if symptoms of heat, heaviness, pressure or tightness (including throat and chest) occur.
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There is limited experience of using 5HT1- receptor agonists during pregnancy; manufacturers advise that they should be avoided unless the potential benefit outweighs the risk.
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Present in milk in animal studies— withhold breast-feeding for 24 hours.
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Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment—no information available.
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Dose adjustments Max. 12.5 mg in 24 hours if eGFR less than 30 mL/minute/1.73 m2.
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 3 ▶Almotriptan (Non-proprietary) Almotriptan (as Almotriptan hydrogen malate) 12.5 mg Almotriptan 12.5mg tablets | 3 tablet P £7.76–£9.07 | 6 tablet P £18.14 DT = £15.93 | 9 tablet P £23.28–£27.20 ▶Almogran (Almirall Ltd) Almotriptan (as Almotriptan hydrogen malate) 12.5 mg Almogran 12.5mg tablets | 3 tablet P £9.07 | 6 tablet P £18.14 DT = £15.93
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12.5 mg, dose to be taken as soon as possible
First-line fragment. Read the complete Indications and Dose section above.
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