Drug Action
Inhibits dipeptidylpeptidase-4 to increase insulin secretion and lower glucagon secretion.
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Drug reference
Inhibits dipeptidylpeptidase-4 to increase insulin secretion and lower glucagon secretion.
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Type 2 diabetes mellitus in combination with other Endocrine system antidiabetic drugs (including insulin) if existing treatment fails to achieve adequate glycaemic control ▶BY MOUTH ▶Adult: 25 mg once daily, for further information on use with other antidiabetic drugs—consult product literature
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DUE TO INTERACTIONS ▶Dose of concomitant sulfonylurea or insulin may need to be reduced. ▶Caution with use in combination with both metformin and pioglitazone—risk of hypoglycaemia (dose of metformin or pioglitazone may need to be reduced).
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Ketoacidosis
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History of pancreatitis. not recommended in moderate to severe heart failure (limited experience)
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Contra-indicated if history of serious hypersensitivity to dipeptidylpeptidase- 4 inhibitors.
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→Appendix 1: alogliptin
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▶Common or very common Abdominal pain. gastrooesophageal reflux disease. headache. increased risk of infection. skin reactions ▶Frequency not known Angioedema. hepatic function abnormal. pancreatitis acute. Stevens-Johnson syndrome SIDE-EFFECTS, FURTHER INFORMATION Discontinue if symptoms of acute pancreatitis occur such as persistent, severe abdominal pain.
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Manufacturer advises avoid—no information available.
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Avoid—present in milk in animal studies.
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Manufacturer advises avoid in severe impairment—no information available.
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Use with caution if eGFR less than 30 mL/minute/1.73 m2. Dose adjustments Reduce dose to 12.5 mg once daily if eGFR 30–50 mL/minute/1.73 m2. Reduce dose to 6.25 mg once daily if eGFR less than 30 mL/minute/1.73 m2.
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Determine renal function before treatment and periodically thereafter.
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There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Vipidia (Takeda UK Ltd) Alogliptin (as Alogliptin benzoate) 6.25 mg Vipidia 6.25mg tablets | 28 tablet P £26.60 DT = £26.60 Alogliptin (as Alogliptin benzoate) 12.5 mg Vipidia 12.5mg tablets | 28 tablet P £26.60 DT = £26.60 Alogliptin (as Alogliptin benzoate) 25 mg Vipidia 25mg tablets | 28 tablet P £26.60 DT = £26.60
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25 mg once daily, for further information on use
First-line fragment. Read the complete Indications and Dose section above.
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