Names and pronunciation
(ah-loss′a-tron) Lotronex
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Drug reference
(ah-loss′a-tron) Lotronex
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Func. class.: Anti-IBS agent
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USES: Severe, chronic, diarrhea- predominant irritable bowel syndrome (IBS) in women who have failed conventional therapy
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CONTRAINDICATIONS: Crohn’s disease, severe hepatic disease, diver- ticulitis, toxic megacolon, GI adhe- sions/strictures/obstruction/perfora- tion, thrombophlebitis, ulcerative colitis
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Black Box Warning: Ischemic colitis, se- vere constipation
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DOSAGE AND ROUTES • Adult woman: PO 0.5 mg bid, may increase to 1 mg bid after 4 wk if well tolerated; if symptoms are not controlled after 4 wk of treatment with 1 mg bid, discontinue
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Available forms: Tablets 0.5 mg, 1 mg HIGH ALERT
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• Adult woman: PO 0.5 mg bid, may increase to 1 mg bid after 4 wk if well tolerated; if symptoms are not controlled after 4 wk of treatment with 1 mg bid, discontinue
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