Indications And Dose
Acute myocardial infarction, accelerated regimen ▶INITIALLY BY INTRAVENOUS INJECTION ▶Adult (body-weight up to 65 kg): Initially 15 mg, to be initiated within 6 hours of symptom onset, followed by (by intravenous infusion) 0.75 mg/kg, to be given over 30 minutes, then (by intravenous infusion) 0.5 mg/kg, to be given over 60 minutes, maximum total dose of 100 mg administered over 90 minutes ▶Adult (body-weight 65 kg and above): Initially 15 mg, to be initiated within 6 hours of symptom onset, followed by (by intravenous infusion) 50 mg, to be given over 30 minutes, then (by intravenous infusion) 35 mg, to be given over 60 minutes, maximum total dose of 100 mg administered over 90 minutes Acute myocardial infarction ▶INITIALLY BY INTRAVENOUS INJECTION ▶Adult: Initially 10 mg, to be initiated within 6–12 hours of symptom onset, followed by (by intravenous infusion) 50 mg, to be given over 60 minutes, then (by intravenous infusion) 10 mg for 4 infusions, each 10 mg infusion dose to be given over 30 minutes, total dose of 100 mg over 3 hours; maximum 1.5 mg/kg in patients less than 65 kg Pulmonary embolism ▶INITIALLY BY INTRAVENOUS INJECTION ▶Adult: Initially 10 mg, to be given over 1–2 minutes, followed by (by intravenous infusion) 90 mg, to be given over 2 hours, maximum 1.5 mg/kg in patients less than 65 kg Acute ischaemic stroke (under specialist neurology physician only) ▶BY INTRAVENOUS INFUSION ▶Adult 18–79 years: Initially 900 micrograms/kg (max. per dose 90 mg), treatment must begin within 4.5 hours of symptom onset, to be given over 60 minutes, the initial 10% of dose is to be administered by intravenous injection and the remainder by intravenous infusion ACTILYSE CATHFLO ® Thrombolytic treatment of occluded central venous access devices (including those used for haemodialysis) ▶BY INTRAVENOUS INJECTION ▶Adult: (consult product literature)
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