Drug reference

Amiloride hydrochloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 265, 266

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Oedema (monotherapy) ▶BY MOUTH ▶Adult: Initially 10 mg daily, alternatively initially 5 mg twice daily, adjusted according to response; maximum 20 mg per day Potassium conservation when used as an adjunct to thiazide or loop diuretics for hypertension or congestive heart failure ▶BY MOUTH ▶Adult: Initially 5–10 mg daily Potassium conservation when used as an adjunct to thiazide or loop diuretics for hepatic cirrhosis with ascites ▶BY MOUTH ▶Adult: Initially 5 mg daily

PDF page 265

Contra Indications

Addison’s disease. anuria. hyperkalaemia

PDF page 265

Cautions

Diabetes mellitus. elderly

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Safety

Interactions

→Appendix 1: potassium-sparing diuretics

PDF page 265

Side Effects

Alopecia. angina pectoris. aplastic anaemia . appetite decreased. arrhythmia. arthralgia. asthenia. atrioventricular block exacerbated. bladder spasm. chest pain. confusion. constipation. cough. depression. diarrhoea. dizziness. drowsiness. dry mouth. dyspnoea. dysuria. electrolyte imbalance. encephalopathy. gastrointestinal discomfort. gastrointestinal disorders. gastrointestinal haemorrhage. gout. headache. insomnia. jaundice. muscle cramps. nasal congestion. nausea. nervousness. neutropenia. pain. palpitations. Cardiovascular system paraesthesia. postural hypotension. sexual dysfunction. skin reactions. tinnitus. tremor. vertigo. visual impairment. vomiting

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Pregnancy

Not to be used to treat gestational hypertension.

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Breast Feeding

Manufacturer advises avoid—no information available.

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Renal Impairment

Manufacturers advise avoid in severe impairment. Monitoring Monitor plasma-potassium concentration (high risk of hyperkalaemia in renal impairment).

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Monitoring Requirements

Monitor electrolytes.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Oral solution EXCIPIENTS: May contain Propylene glycol ▶Amiloride hydrochloride (Non-proprietary) Amiloride hydrochloride 1 mg per 1 ml Amiloride 5mg/5ml oral solution sugar-free | 150 ml P £46.45 DT = £42.35 Tablet ▶Amiloride hydrochloride (Non-proprietary) Amiloride hydrochloride 5 mg Amiloride 5mg tablets | 28 tablet P £34.50 DT = £16.69 Combinations available: Co-amilofruse, p. 241

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Dose text by age group

Adult

Initially 10 mg daily, alternatively initially 5 mg

First-line fragment. Read the complete Indications and Dose section above.

PDF page 265

Adult

Initially 5–10 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 265

Adult

Initially 5 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 265

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Amiloride hydrochloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 265, 266

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 265

Contra Indications

Addison’s disease. anuria. hyperkalaemia

PDF page 265

Cautions

Diabetes mellitus. elderly

PDF page 265

Safety

Interactions

→Appendix 1: potassium-sparing diuretics

PDF page 265

Side Effects

PDF pages 265, 266

Pregnancy

Not to be used to treat gestational hypertension.

PDF page 266

Breast Feeding

Manufacturer advises avoid—no information available.

PDF page 266

Renal Impairment

Manufacturers advise avoid in severe impairment. Monitoring Monitor plasma-potassium concentration (high risk of hyperkalaemia in renal impairment).

PDF page 266

Monitoring Requirements

Monitor electrolytes.

PDF page 266

Dose and formulations

Medicinal Forms

PDF page 266

Dose text by age group

Adult

Initially 10 mg daily, alternatively initially 5 mg

First-line fragment. Read the complete Indications and Dose section above.

PDF page 265

Adult

Initially 5–10 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 265

Adult

Initially 5 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 265

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.