Drug reference
Multiple-drug resistant tuberculosis, in combination with other drugs ▶BY MOUTH ▶Adult: 4 g every 8 hours for a usual treatment duration of 24 months; maximum 12 g per day Desensitisation regimen ▶BY MOUTH ▶Adult: (consult product literature)
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Peptic ulcer
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→Appendix 1: aminosalicylic acid
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▶Common or very common Diarrhoea. dizziness. gastrointestinal discomfort. gastrointestinal disorders. hypersensitivity. nausea. skin reactions. vestibular syndrome. vomiting ▶Uncommon Appetite decreased ▶Rare or very rare Agranulocytosis. anaemia. crystalluria. gastrointestinal haemorrhage. headache. hepatic disorders. hypoglycaemia. hypothyroidism. leucopenia. methaemoglobinaemia. peripheral neuropathy. taste metallic. tendon pain. thrombocytopenia. visual impairment. weight decreased
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Manufacturer advises avoid unless essential—toxicity in animal studies (highest risk during first trimester).
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Present in milk—manufacturer advises avoid.
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Manufacturer advises use with caution.
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Use with caution in mild to moderate impairment. Avoid in severe impairment due to accumulation of inactive metabolites.
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▶Monitor for hypersensitivity reaction during the first 3 months of treatment—for desensitisation dosing regimen consult product literature. ▶Monitor liver function—discontinue immediately if signs or symptoms of hepatic toxicity (including rash, fever and gastrointestinal disturbance).
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Disperse granules in orange or tomato juice and take immediately (granules will not dissolve, ensure all granules are swallowed). Granules can be sprinkled on apple sauce or yoghurt for administration.
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There can be variation in the licensing of different medicines containing the same drug. Gastro-resistant granules CAUTIONARY AND ADVISORY LABELS 9, 25 ▶Granupas (Eurocept International bv) Aminosalicylic acid 1 gram per 1 gram Granupas gastro-resistant granules 4g sachets sugar-free | 30 sachet P £331.00 DT = £331.00
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Patients should be advised that the skeletons of the granules may be seen in the stools. Counselling advised on administration.
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4 g every 8 hours for a usual treatment duration
First-line fragment. Read the complete Indications and Dose section above.
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(consult product literature)
First-line fragment. Read the complete Indications and Dose section above.
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