Drug Action
Amisulpride is a selective dopamine receptor antagonist with high affinity for mesolimbic D2 and D3 receptors.
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Drug reference
Amisulpride is a selective dopamine receptor antagonist with high affinity for mesolimbic D2 and D3 receptors.
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Acute psychotic episode in schizophrenia ▶BY MOUTH ▶Adult: 400–800 mg daily in 2 divided doses, adjusted according to response; maximum 1.2 g per day Schizophrenia with predominantly negative symptoms ▶BY MOUTH ▶Adult: 50–300 mg daily
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CNS depression. comatose states. phaeochromocytoma. prolactin-dependent tumours
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Flavours of oral liquid formulations may include caramel.
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→Appendix 1: amisulpride
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▶Common or very common Anxiety. breast pain. hypersalivation. muscle rigidity. nausea. oculogyric crisis . orgasm abnormal. trismus ▶Uncommon Hyperglycaemia ▶Frequency not known Angioedema. bone disorders. cardiac arrest. confusion. dyslipidaemia. hyponatraemia. nasal congestion. neoplasms. SIADH. urticaria. vision blurred
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Avoid.
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Avoid—no information available.
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No information available if eGFR less than 10 mL/minute/1.73 m2. Dose adjustments Halve dose if eGFR 30–60 mL/minute/ 1.73 m2. Use one-third dose if eGFR 10–30 mL/minute/ 1.73 m2.
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Amisulpride does not affect blood pressure to the same extent as other antipsychotic drugs and so blood pressure monitoring is not mandatory for this drug.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Oral solution CAUTIONARY AND ADVISORY LABELS 2 ▶Amisulpride (Non-proprietary) Amisulpride 100 mg per 1 ml Amisulpride 100mg/ml oral solution sugar free sugar-free | 60 ml P £88.50 DT = £77.13 ▶Solian (Sanofi) Amisulpride 100 mg per 1 ml Solian 100mg/ml oral solution sugar- free | 60 ml P £33.76 DT = £77.13 Tablet CAUTIONARY AND ADVISORY LABELS 2 ▶Amisulpride (Non-proprietary) Amisulpride 50 mg Amisulpride 50mg tablets | 60 tablet P £19.74 DT = £5.39 Amisulpride 100 mg Amisulpride 100mg tablets | 60 tablet P £39.48 DT = £9.10 Amisulpride 200 mg Amisulpride 200mg tablets | 60 tablet P £66.00 DT = £12.85 Amisulpride 400 mg Amisulpride 400mg tablets | 60 tablet P £132.00 DT = £42.08 ▶Solian (Sanofi) Amisulpride 50 mg Solian 50 tablets | 60 tablet P £22.76 DT = £5.39 Amisulpride 100 mg Solian 100 tablets | 60 tablet P £35.29 DT = £9.10 Amisulpride 200 mg Solian 200 tablets | 60 tablet P £58.99 DT = £12.85 Amisulpride 400 mg Solian 400 tablets | 60 tablet P £117.97 DT = £42.08 eiiii F 401
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400–800 mg daily in 2 divided doses, adjusted
First-line fragment. Read the complete Indications and Dose section above.
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50–300 mg daily
First-line fragment. Read the complete Indications and Dose section above.
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