Drug reference
Combination of two antibacterials. The addition of clavulanic acid to amoxicillin extends its spectrum of activity to cover beta-lactamase producing Gram-positive and Gram-negative organisms, including some Gram-negative anaerobes.
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Animal bites, if antibiotic therapy or antibiotic prophylaxis is clearly indicated Second line treatment of acute otitis media and acute bacterial sinusitis, when amoxicillin alone given at high dose failed Acute uncomplicated cystitis (no systemic signs) in girls over 2 years Postpartum upper genital tract infection Parenteral to oral switch therapy in severe infections (e.g. severe pneumonia)
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Do not administer to penicillin-allergic patients and patients with history of hepatic disorders during a previous treatment with co-amoxiclav. Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur). Administer with caution to patients with hepatic impairment; reduce dosage and give every 12 or 24 hours in patients with severe renal impairment. May cause: gastrointestinal disturbances (mainly diarrhoea); allergic reactions sometimes severe (stop treatment immediately); jaundice and cholestatic hepatitis in the event of prolonged treatment (> 10 to 15 days). The dose of clavulanic acid should not exceed 12.5 mg/kg daily or 375 mg daily. Pregnancy: no contra-indication Breast-feeding: no contra-indication
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The ratio of amoxicillin and clavulanic acid varies according to the manufacturer: Ratio 8:1 500 mg amoxicillin/62.5 mg clavulanic acid tablet 500 mg amoxicillin/62.5 mg clavulanic acid/5 ml powder for oral suspension Ratio 7:1 875 mg amoxicillin/125 mg clavulanic acid tablet 400 mg amoxicillin/57 mg clavulanic acid/5 ml, powder for oral suspension 200 mg amoxicillin/28.5 mg clavulanic acid dispersible tablet
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(expressed in amoxicillin) Animal bites; second line treatment of acute otitis media and acute sinusitis Child < 40 kg: 25 mg/kg 2 times daily Child ≥ 40 kg and adult: Ratio 8:1: 2000 mg daily = 2 tablets of 500/62.5 mg 2 times daily Ratio 7:1: 1750 mg daily = 1 tablet of 875/125 mg 2 times daily Acute uncomplicated cystitis in girls > 2 years 12.5 mg/kg 2 times daily Postpartum upper genital tract infection; parenteral to oral switch therapy in severe infections Child < 40 kg: 50 mg/kg 2 times daily Child ≥ 40 kg and adult: Ratio 8:1: 3000 mg daily = 2 tablets of 500/62.5 mg 3 times daily Ratio 7:1: 2625 mg daily = 1 tablet of 875/125 mg 3 times daily
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Animal bites: 5 to 7 days Otitis media: 5 days Sinusitis: 7 to 10 days Cystitis: 3 days Upper genital tract infection: 7 days Parenteral to oral switch therapy in severe pneumonia: to complete a total of 10 to 14 days of treatment.
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Take with meals. Also comes in formulations with a ratio of amoxicillin/clavulanic acid of 4:1: 125 mg amoxicillin/31.25 mg clavulanic acid/5 ml powder for oral suspension and 500 mg amoxicillin/125 mg clavulanic acid tablet. The maximum dose (expressed in amoxicillin) that can be given with these formulations is 50 mg/kg daily, without exceeding 1500 mg daily.
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– – Below 25 °C
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25 mg/kg 2 times daily
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50 mg/kg 2 times daily
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