Drug reference
Penicillin antibacterial, combined with a beta-lactamase inhibitor. The addition of clavulanic acid to amoxicillin extends its spectrum of activity to cover beta-lactamase producing Gram-positive and Gram-negative organisms, including some Gram-negative anaerobes.
PDF page 346
Erysipelas and cellulitis Necrotizing infections of the skin and soft tissues (necrotizing fasciitis, gas gangrene, etc.), in combination with clindamycin Severe postpartum upper genital tract infection, in combination with gentamicin
PDF page 346
Do not administer to penicillin-allergic patients, patients with history of hepatic disorders during a previous treatment with co-amoxiclav, patients with infectious mononucleosis. Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur), patients with hepatic impairment or severe renal impairment (reduce dosage and give every 12 or 24 hours). May cause: diarrhoea; hepatic disorders (avoid treatments longer than 14 days); allergic reactions sometimes severe. Do not combine with methotrexate (increased methotrexate toxicity). Pregnancy: no contra-indication Breast-feeding: no contra-indication
PDF page 347
Powder for injection, in 1 g amoxicillin/200 mg clavulanic acid vial, to be dissolved in 20 ml water for injection or 0.9% sodium chloride, for slow IV injection (3 minutes) or IV infusion (30 minutes). DO NOT DILUTE IN GLUCOSE.
PDF page 346
Doses expressed in amoxicillin: Erysipelas, cellulitis Child under 3 months: 30 mg/kg every 12 hours Child 3 months and over: 20 to 30 mg/kg every 8 hours (max. 3 g daily) Adult: 1 g every 8 hours Necrotizing infections Child under 3 months: 50 mg/kg every 12 hours Child 3 months and over and < 40 kg: 50 mg/kg every 8 hours (max. 6 g daily) Child 40 kg and over and adult: 2 g every 8 hours Upper genital tract infection Adult: 1 g every 8 hours For administration by IV infusion, dilute each dose of amoxicillin/clavulanic acid in 5 ml/kg of 0.9% sodium chloride in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride in children 20 kg and over and in adults.
PDF pages 346, 347
Erysipelas, cellulitis: 7 to 10 days Necrotizing infections: 14 days Upper genital tract infection: depending on clinical response Change to oral treatment as soon as possible.
PDF page 347
Do not mix with other drugs in the same syringe or infusion bag.
PDF page 347
Below 25 °C Once reconstituted, the solution must be used immediately; discard any unused open vial.
PDF page 347
1 g every 8 hours
PDF page 346
2 g every 8 hours
PDF page 346
1 g every 8 hours
PDF page 347
