Indications And Dose
ABELCET ® Severe invasive candidiasis | Severe systemic fungal infections in patients not responding to conventional amphotericin or to other antifungal drugs or where toxicity or renal impairment precludes conventional amphotericin, including invasive aspergillosis, cryptococcal meningitis and disseminated cryptococcosis in HIV patients ▶BY INTRAVENOUS INFUSION ▶Adult: Test dose 1 mg, to be given over 15 minutes, then 5 mg/kg once daily for at least 14 days AMBISOME ® Severe systemic or deep mycoses where toxicity (particularly nephrotoxicity) precludes use of conventional amphotericin | Suspected or proven infection in febrile neutropenic patients unresponsive to broad-spectrum antibacterials ▶BY INTRAVENOUS INFUSION ▶Adult: Test dose 1 mg, to be given over 10 minutes, then 3 mg/kg once daily; maximum 5 mg/kg per day Aspergillosis ▶BY INTRAVENOUS INFUSION ▶Adult: Test dose 1 mg, to be given over 10 minutes, then 3 mg/kg once daily; maximum 5 mg/kg per day Visceral leishmaniasis (unresponsive to the antimonial alone) ▶BY INTRAVENOUS INFUSION ▶Adult: 1–3 mg/kg daily for 10–21 days to a cumulative dose of 21–30 mg/kg, alternatively 3 mg/kg for 5 consecutive days, followed by 3 mg/kg after 6 days for 1 dose FUNGIZONE ® Systemic fungal infections ▶BY INTRAVENOUS INFUSION ▶Adult: Test dose 1 mg, to be given over 20–30 minutes, then 250 micrograms/kg daily, gradually increased over 2–4 days, increased if tolerated to 1 mg/kg daily, max. (severe infection) 1.5 mg/kg daily or on alternate days. Prolonged treatment usually necessary; if interrupted for longer than 7 days recommence at 250 micrograms/kg daily and increase gradually l UNLICENSED USE AMBISOME ® Use at the maximum dose of 5 mg/kg once daily is an unlicensed dose.
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