Drug Action
Andexanet alfa is a recombinant form of human factor Xa protein which binds specifically to apixaban or rivaroxaban, thereby reversing their anticoagulant effects.
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Drug reference
Andexanet alfa is a recombinant form of human factor Xa protein which binds specifically to apixaban or rivaroxaban, thereby reversing their anticoagulant effects.
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Reversal of apixaban or rivaroxaban in life-threatening or uncontrolled bleeding (specialist supervision in hospital) ▶BY INTRAVENOUS INFUSION ▶Adult: (consult product literature)
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Risk of thrombosis CAUTIONS, FURTHER INFORMATION Manufacturer advises to consider re-starting anticoagulant therapy as soon as medically appropriate to reduce the risk of thrombosis.
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▶Common or very common Back pain. cerebrovascular insufficiency. chest discomfort. cough. dizziness postural . dry mouth. dyspnoea. feeling hot. fever. flushing. gastrointestinal discomfort. headache. hyperhidrosis. muscle spasms. nausea. palpitations. peripheral coldness . skin reactions. taste altered ▶Uncommon Cardiac arrest. embolism and thrombosis. iliac artery occlusion. myocardial infarction
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Manufacturer advises avoid—no information available.
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Manufacturer advises discontinue breast-feeding—no information available. l HANDLING AND STORAGE Manufacturer advises store in a refrigerator (2–8°C)—consult product literature about storage after reconstitution.
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There can be variation in the licensing of different medicines containing the same drug. Powder for solution for infusion EXCIPIENTS: May contain Polysorbates, sucrose A ▶Andexanet alfa (non-proprietary) Andexanet alfa 200 mg Ondexxya 200mg powder for solution for infusion vials | 4 vial P £11,100.00 (Hospital only)
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(consult product literature)
First-line fragment. Read the complete Indications and Dose section above.
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