Names and pronunciation
(an-tee-hee-moe-fil′ik fak′tor) Eloctate
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Drug reference
(an-tee-hee-moe-fil′ik fak′tor) Eloctate
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Func. class.: Hemostatic
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USES: Hemophilia A (congenital fac- tor VIII deficiency), control/prevention of bleeding, perioperative management of surgical bleeding
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DOSAGE AND ROUTES Hemophilia A (congenital factor VIII deficiency) • Adults, adolescents, children, infants, and neonates: IV INFUSION Infuse dose ≤10 mL/min; dose (IU) = body weight (kg) × desired factor VIII increase (IU/ dL or % of normal) × 0.5 (IU/kg per IU/ dL) OR estimated increment of factor VIII (IU/dL or % of normal) = [total dose (IU)/body weight (kg)] × 2 (IU/dL per IU/kg) Control/prevention of bleeding • Adults, adolescents, children, infants, and neonates: Dose and duration of treatment depend on the severity of the factor VIII deficiency, the location and extent of bleeding, and the patient’s clin- ical condition Perioperative management of surgi- cal bleeding • Adults, adolescents, children, infants, and neonates: Dose and duration of treatment depend on the severity of the factor VIII deficiency, the location and extent of bleeding, and the patient’s clin- ical condition Routine bleeding prophylaxis to prevent/reduce the frequency of bleeding episodes • IV Initially, 50 IU/kg q4days; adjust dose based on response HIGH ALERT
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• Adults, adolescents, children, infants, and neonates: IV INFUSION Infuse dose ≤10 mL/min; dose (IU) = body weight (kg) × desired factor VIII increase (IU/ dL or % of normal) × 0.5 (IU/kg per IU/ dL) OR estimated increment of factor VIII (IU/dL or % of normal) = [total dose (IU)/body weight (kg)] × 2 (IU/dL per IU/kg) Control/prevention of bleeding
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• Adults, adolescents, children, infants, and neonates: Dose and duration of treatment depend on the severity of the factor VIII deficiency, the location and extent of bleeding, and the patient’s clin- ical condition Perioperative management of surgi- cal bleeding
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• Adults, adolescents, children, infants, and neonates: Dose and duration of treatment depend on the severity of the factor VIII deficiency, the location and extent of bleeding, and the patient’s clin- ical condition Routine bleeding prophylaxis to prevent/reduce the frequency of bleeding episodes
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• IV Initially, 50 IU/kg q4days; adjust dose based on response HIGH ALERT
PDF page 96