Drug reference
Adjunct treatment to prevent nausea and vomiting associated with moderately and highly emetogenic chemotherapy ▶BY MOUTH ▶Adult: Initially 125 mg, dose to be taken 1 hour before chemotherapy, then 80 mg once daily for 2 days, consult product literature for dose of concomitant dexamethasone and 5HT3-antagonist
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Acute porphyrias p. 1120
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→Appendix 1: aprepitant
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▶Common or very common Appetite decreased. asthenia. constipation. gastrointestinal discomfort. headache. hiccups ▶Uncommon Anaemia. anxiety. burping. dizziness. drowsiness. dry mouth. febrile neutropenia. gastrointestinal disorders. hot flush. malaise. nausea. palpitations. skin reactions. urinary disorders. vomiting ▶Rare or very rare Bradycardia. cardiovascular disorder. chest discomfort. cognitive disorder. conjunctivitis. cough. disorientation. euphoric mood. gait abnormal. hyperhidrosis. increased risk of infection. muscle spasms. muscle weakness. oedema. oropharyngeal pain. photosensitivity reaction. polydipsia. seborrhoea. severe cutaneous adverse reactions (SCARs). sneezing. stomatitis. taste altered. throat irritation. tinnitus. weight decreased ▶Frequency not known Dysarthria. dyspnoea. insomnia. miosis. sensation abnormal. visual acuity decreased. wheezing
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Manufacturer advises effectiveness of hormonal contraceptives may be reduced—alternative non-hormonal methods of contraception necessary during treatment and for 2 months after stopping aprepitant.
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Manufacturer advises avoid unless clearly necessary—no information available.
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Manufacturer advises avoid—present in milk in animal studies.
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Manufacturer advises caution in moderate to severe impairment—limited information available.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension Capsule ▶Aprepitant (Non-proprietary) Aprepitant 80 mg Aprepitant 80mg capsules | 2 capsule P £26.87–£31.61 DT = £31.61 | 2 capsule P £31.61 DT = £31.61 Nervous system (Hospital only) Aprepitant 125 mg Aprepitant 125mg capsules | 5 capsule P £67.18–£79.03 DT = £79.03 | 5 capsule P £79.03 DT = £79.03 (Hospital only) ▶Emend (Merck Sharp & Dohme Ltd) Aprepitant 80 mg Emend 80mg capsules | 2 capsule P £31.61 DT = £31.61 Aprepitant 125 mg Emend 125mg capsules | 5 capsule P £79.03 DT = £79.03
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Initially 125 mg, dose to be taken 1 hour before
First-line fragment. Read the complete Indications and Dose section above.
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