Names and pronunciation
Erwinaze, Kidrolase
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Drug reference
Erwinaze, Kidrolase
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Func. class.: Antineoplastic, natural and semisynthetic
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USES: Treatment of acute lymphocytic leukemia (ALL) in combination with other chemotherapeutic agents in patients who have developed hypersensi- tivity to Escherichia coli–derived asparaginase
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CONTRAINDICATIONS: Hyper- sensitivity, breastfeeding, history of serious pancreatitis, bleeding, or serious throm- bosis with prior l-asparaginase therapy
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DOSAGE AND ROUTES • Adult, adolescent, child ≥2 yr (substi- tute for pegaspargase): IM 25,000 IU/ m2 3×/wk (Monday/Wednesday/Friday) × 6 doses for each planned dose of pegaspargase within a treatment • Adult (substitute for l-asparaginase E. coli): IM 25,000 IU/m2 for each sched- uled dose of native E. coli asparaginase within a treatment
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Available forms: powder for injection 10,000 IU/vial
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• Adult, adolescent, child ≥2 yr (substi- tute for pegaspargase): IM 25,000 IU/ m2 3×/wk (Monday/Wednesday/Friday) × 6 doses for each planned dose of pegaspargase within a treatment
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