Drug reference
HIV infection in combination with other antiretroviral drugs—with low-dose ritonavir ▶BY MOUTH ▶Adult: 300 mg once daily HIV infection in combination with other antiretroviral drugs—with cobicistat ▶BY MOUTH ▶Adult: 300 mg daily
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Cardiac conduction disorders. electrolyte disturbances. predisposition to QT interval prolongation
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→Appendix 1: HIV-protease inhibitors
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▶Uncommon Chest pain. chronic kidney disease. depression. disorientation. drug reaction with eosinophilia and systemic symptoms (DRESS). gallbladder disorders. gynaecomastia. haematuria. memory loss. myopathy. nephritis tubulointerstitial. nephrolithiasis. proteinuria. syncope. torsade de pointes. urinary frequency increased ▶Rare or very rare Gait abnormal. oedema. palpitations. QT interval prolongation. renal pain. vasodilation SIDE-EFFECTS, FURTHER INFORMATION Mild to moderate Infection rash occurs commonly, usually within the first 3 weeks of therapy. Severe rash occurs less frequently and may be accompanied by systemic symptoms. Discontinue if severe rash develops.
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Theoretical risk of hyperbilirubinaemia in neonate if used at term. Monitoring In pregnancy, monitor viral load and plasma- atazanavir concentration during third trimester.
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Manufacturer advises caution in mild impairment; avoid in moderate to severe impairment (no information available).
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There can be variation in the licensing of different medicines containing the same drug. Capsule CAUTIONARY AND ADVISORY LABELS 5, 21 ▶Atazanavir (Non-proprietary) Atazanavir (as Atazanavir sulfate) 150 mg Atazanavir 150mg capsules | 60 capsule P £303.38 Atazanavir (as Atazanavir sulfate) 200 mg Atazanavir 200mg capsules | 60 capsule P £303.37–£303.38 | 60 capsule P £303.37 (Hospital only) Atazanavir (as Atazanavir sulfate) 300 mg Atazanavir 300mg capsules | 30 capsule P £303.37 (Hospital only) | 30 capsule P £257.87–£303.38 ▶Reyataz (Bristol-Myers Squibb Pharmaceuticals Ltd) Atazanavir (as Atazanavir sulfate) 150 mg Reyataz 150mg capsules | 60 capsule P £303.38 (Hospital only) Atazanavir (as Atazanavir sulfate) 200 mg Reyataz 200mg capsules | 60 capsule P £303.38 (Hospital only) Atazanavir (as Atazanavir sulfate) 300 mg Reyataz 300mg capsules | 30 capsule P £303.38 (Hospital only)
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300 mg once daily
First-line fragment. Read the complete Indications and Dose section above.
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300 mg daily
First-line fragment. Read the complete Indications and Dose section above.
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