Drug reference
Uncomplicated premature labour between 24 and 33 weeks of gestation ▶INITIALLY BY INTRAVENOUS INJECTION ▶Adult: Initially 6.75 mg over 1 minute, then (by intravenous infusion) 18 mg/hour for 3 hours, then (by intravenous infusion) reduced to 6 mg/hour for up to 45 hours. Maximum duration of treatment is 48 hours
PDF page 893
Abnormal fetal heart rate. abruptio placenta. antepartum haemorrhage (requiring immediate delivery). eclampsia. intra-uterine fetal death. intra- uterine infection. placenta praevia. premature rupture of membranes after 30 weeks’ gestation. severe pre- eclampsia
PDF page 893
Abnormal placental site. intra-uterine growth restriction
PDF page 893
▶Common or very common Dizziness. headache. hot flush. hyperglycaemia. hypotension. nausea. tachycardia. vomiting ▶Uncommon Fever. insomnia. skin reactions ▶Rare or very rare Uterine atony. uterine haemorrhage ▶Frequency not known Dyspnoea. pulmonary oedema
PDF page 893
Manufacturer advises caution—no information available.
PDF page 893
No information available.
PDF page 893
Monitor blood loss after delivery.
PDF page 893
For intravenous infusion (Tractocile ® concentrate for intravenous infusion), give continuously in Glucose 5% or Sodium chloride 0.9%. Withdraw 10 mL infusion fluid from 100-mL bag and replace with 10 mL atosiban concentrate (7.5 mg/mL) to produce a final concentration of 750 micrograms/mL.
PDF page 893
There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Atosiban (Non-proprietary) Atosiban (as Atosiban acetate) 7.5 mg per 1 ml Atosiban 6.75mg/0.9ml solution for injection vials | 1 vial P £18.41 (Hospital only) Atosiban 6.75mg/0.9ml solution for injection pre-filled syringes | 1 pre-filled disposable injection P £18.41 (Hospital only) ▶Tractocile (Ferring Pharmaceuticals Ltd) Atosiban (as Atosiban acetate) 7.5 mg per 1 ml Tractocile 6.75mg/0.9ml solution for injection vials | 1 vial P £18.41 (Hospital only) Solution for infusion ▶Atosiban (Non-proprietary) Atosiban (as Atosiban acetate) 7.5 mg per 1 ml Atosiban 37.5mg/5ml concentrate for solution for infusion vials | 1 vial P £50.18–£52.82 (Hospital only) Atosiban 6.75mg/0.9ml solution for injection ampoules | 1 ampoule P £17.99 (Hospital only) ▶Tractocile (Ferring Pharmaceuticals Ltd) Atosiban (as Atosiban acetate) 7.5 mg per 1 ml Tractocile 37.5mg/5ml solution for infusion vials | 1 vial P £52.82 (Hospital only) 5.4 Termination of pregnancy PROGESTERONE RECEPTOR MODULATORS
PDF page 893
Initially 6.75 mg over 1 minute, then (by
First-line fragment. Read the complete Indications and Dose section above.
PDF page 893
