Therapeutic Action
Parasympatholytic, antispasmodic
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Drug reference
Parasympatholytic, antispasmodic
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Premedication in anaesthesia Spasms of the gastrointestinal tract Organophosphorus pesticide poisoning
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Do not administer to patients with urethro-prostatic disorders, cardiac disorders, glaucoma. Do not administer to children with high fever. May cause: urinary retention, dryness of the mouth, constipation, dizziness, headache, dilatation of the pupils, tachycardia. Administer with caution and under close supervision to patients taking other anticholinergic drugs (antidepressants, neuroleptics, H1 antihistamines, antiparkinsonians, etc.). Pregnancy: no contra-indication; NO PROLONGED TREATMENT Breast-feeding: avoid; NO PROLONGED TREATMENT
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1 mg atropine sulfate in 1 ml ampoule (1 mg/ml) for SC, IM, IV injection Also comes in 0.25 mg/ml and 0.5 mg/ml ampoules.
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Premedication in anaesthesia Child: 0.01 to 0.02 mg/kg by SC or IV injection Adult: 1 mg by SC or IV injection Spasms of the gastrointestinal tract Child from 2 to 6 years: 0.25 mg by SC injection, single dose Child over 6 years: 0.5 mg by SC injection, single dose Adult: 0.25 to 1 mg by SC injection, every 6 hours if necessary (max. 2 mg daily) Organophosphorus pesticide poisoning Child: 0.02 to 0.05 mg/kg by IM or slow IV injection Adult: 2 mg by IM or slow IV injection Repeat every 5 to 10 minutes until signs of atropinisation appear (reduced secretions, tachycardia, dilatation of the pupils).
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Atropine IV is also used to prevent bradycardic effects of neostigmine when used to reverse the effects of competitive muscle relaxants: 0.02 mg/kg in children; 1 mg in adults. Do not mix with other drugs in the same syringe.
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– Below 25 °C
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1 mg by SC or IV injection
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0.25 to 1 mg by SC injection, every 6 hours if necessary (max. 2 mg daily)
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2 mg by IM or slow IV injection
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