Drug reference

Bacillus Calmette-Guérin

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1032

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Bacillus Calmette-Guérin is a live attenuated strain derived from Mycobacterium bovis.

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Indications And Dose

Bladder instillation for the treatment of primary or recurrent bladder carcinoma and for the prevention of recurrence following transurethral resection ▶BY INTRAVESICAL INSTILLATION ▶Adult: (consult product literature)

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Contra Indications

Fever of unknown origin. HIV infection. impaired immune response. severe haematuria . tuberculosis. urinary-tract infection

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Cautions

Bladder injury (delay administration until mucosal damage healed). traumatic catheterisation (delay administration until mucosal damage healed). urethral injury (delay administration until mucosal damage healed)

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Pre Treatment Screening

Screen for active tuberculosis (contra-indicated if tuberculosis conﬁrmed).

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Safety

Side Effects

▶Common or very common Appetite decreased. arthritis. bladder cramps. bladder disorders. cardiovascular event. chills. cystitis. diarrhoea. fatigue. fever. haematuria. hepatic disorders. increased risk of infection. joint disorders. malaise. myalgia. nausea. pain. skin reactions . urinary disorders. vomiting ▶Uncommon Abdominal pain. anaemia. coagulation disorder. constipation. dizziness. genital pain. headache. leucopenia. mucositis. nephrotoxicity. stomatitis. thrombocytopenia. tissue in urine. ulcer. ureteral obstruction ▶Frequency not known Erythema nodosum. eye disorders. eye inﬂammation. glomerulonephritis. inﬂuenza like illness. interstitial lung disease. nephritis. renal abscess. renal failure

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Pregnancy

Avoid.

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Breast Feeding

Avoid.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Powder for reconstitution for instillation ▶OncoTICE (Merck Sharp & Dohme Ltd) TICE strain Bacillus of Calmette-Guerin 12.5 mg OncoTICE 12.5mg powder for reconstitution for instillation vials | 1 vial P £71.61 (Hospital only)

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Dose text by age group

Adult

(consult product literature)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1032

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Bacillus Calmette-Guérin

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1032

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Drug Action

Bacillus Calmette-Guérin is a live attenuated strain derived from Mycobacterium bovis.

PDF page 1032

Indications And Dose

PDF page 1032

Contra Indications

Fever of unknown origin. HIV infection. impaired immune response. severe haematuria . tuberculosis. urinary-tract infection

PDF page 1032

Cautions

PDF page 1032

Pre Treatment Screening

Screen for active tuberculosis (contra-indicated if tuberculosis conﬁrmed).

PDF page 1032

Safety

Side Effects

PDF page 1032

Pregnancy

Avoid.

PDF page 1032

Breast Feeding

Avoid.

PDF page 1032

Dose and formulations

Medicinal Forms

PDF page 1032

Dose text by age group

Adult

(consult product literature)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1032

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.