Names and pronunciation
(bas-ih-liks′ih-mab) Simulect
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Drug reference
(bas-ih-liks′ih-mab) Simulect
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Func. class.: Immunosuppressant
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USES: Acute allograft rejection in renal transplant patients when used with cycloSPORINE and corticosteroids
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CONTRAINDICATIONS: Manni- tol, murine protein hypersensitivity Precautions: Pregnancy, children, geri- atric patients, human antimurine antibody, infections, breastfeeding, neo- plastic disease, vaccination
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Black Box Warning: Requires a spe- cialized care setting and experienced clinician
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DOSAGE AND ROUTES Acute kidney transplant rejection prophylaxis • Adults, adolescents, and children ≥35 kg: IV 20 mg within 2 hr before trans- plantation, then 20 mg IV 4 days after surgery • Children and adolescents <35 kg: IV 10 mg within 2 hr before transplantation, then 10 mg IV 4 days after transplantation For acute liver transplant rejection prophylaxis (unlabeled) • Adults: IV 20 mg within 2 hr of graft reperfusion, then 20 mg IV 4 days after transplantation
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Available forms: injection 10, 20 mg vials
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• Adults, adolescents, and children ≥35 kg: IV 20 mg within 2 hr before trans- plantation, then 20 mg IV 4 days after surgery
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• Children and adolescents <35 kg: IV 10 mg within 2 hr before transplantation, then 10 mg IV 4 days after transplantation For acute liver transplant rejection prophylaxis (unlabeled)
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