Drug reference

Beclometasone dipropionate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 293, 294

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Prophylaxis of asthma ▶BY INHALATION OF POWDER ▶Child 5–11 years: 100–200 micrograms twice daily, dose to be adjusted as necessary ▶Child 12–17 years: 200–400 micrograms twice daily; increased if necessary up to 800 micrograms twice daily, dose to be adjusted as necessary ▶Adult: 200–400 micrograms twice daily; increased if necessary up to 800 micrograms twice daily, dose to be adjusted as necessary DOSE EQUIVALENCE AND CONVERSION ▶Dose adjustments may be required for some inhaler devices, see under individual preparations. CLENIL MODULITE ® Prophylaxis of asthma ▶BY INHALATION OF AEROSOL ▶Child 2–11 years: 100–200 micrograms twice daily ▶Child 12–17 years: 200–400 micrograms twice daily, Respiratory system adjusted according to response; increased if necessary up to 1 mg twice daily ▶Adult: 200–400 micrograms twice daily, adjusted according to response; increased if necessary up to 1 mg twice daily KELHALE ® Prophylaxis of asthma ▶BY INHALATION OF AEROSOL ▶Adult: 50–200 micrograms twice daily; increased if necessary up to 400 micrograms twice daily POTENCY ▶Kelhale ® has extra-ﬁne particles and is more potent than traditional beclometasone dipropionate CFC- containing inhalers. QVAR ® PREPARATIONS Prophylaxis of asthma ▶BY INHALATION OF AEROSOL ▶Child 5–11 years: 50–100 micrograms twice daily ▶Child 12–17 years: 50–200 micrograms twice daily; increased if necessary up to 400 micrograms twice daily ▶Adult: 50–200 micrograms twice daily; increased if necessary up to 400 micrograms twice daily POTENCY ▶Qvar ® has extra-ﬁne particles, is more potent than traditional beclometasone dipropionate CFC- containing inhalers and is approximately twice as potent as Clenil Modulite ®. SOPROBEC ® Prophylaxis of asthma ▶BY INHALATION OF AEROSOL ▶Child: 100 micrograms twice daily; increased if necessary up to 400 micrograms daily in 2–4 divided doses ▶Adult: 200 micrograms twice daily, adjusted according to response; increased if necessary up to 2 mg daily in 2–4 divided doses l UNLICENSED USE ▶In children Easyhaler ® Beclometasone Dipropionate is not licensed for use in children. Clenil Modulite ® 200 and 250 are not licensed for use in children.

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Prescribing And Dispensing Information

The MHRA has advised (July 2008) that beclometasone dipropionate CFC-free inhalers should be prescribed by brand name. Pressurised metered-doses inhalers with extra-ﬁne particles (Qvar ® and Kelhale ®) are more potent than, and not interchangeable with, traditional CFC-containing and CFC-free inhalers (Clenil Modulite ® and Soprobec ®). KELHALE ® Manufacturer advises when switching a patient with well-controlled asthma from another corticosteroid inhaler, initially a 100-microgram metered dose of Kelhale ® should be prescribed for 200–250 micrograms of Respiratory system budesonide and for 100 micrograms of ﬂuticasone propionate; the dose of Kelhale ® should be adjusted according to response, up to a maximum of 800 micrograms daily. Manufacturer advises when switching a patient with poorly-controlled asthma from another corticosteroid inhaler, initially a 100-microgram metered dose of Kelhale ® should be prescribed for 100 micrograms of budesonide or ﬂuticasone propionate; the dose of Kelhale ® should be adjusted according to response, up to a maximum of 800 micrograms daily. QVAR ® PREPARATIONS When switching a patient with well-controlled asthma from another corticosteroid inhaler, initially a 100-microgram metered dose of Qvar ® should be prescribed for 200–250 micrograms of beclometasone dipropionate or budesonide and for 100 micrograms of ﬂuticasone propionate. When switching a patient with poorly controlled asthma from another corticosteroid inhaler, initially a 100-microgram metered dose of Qvar ® should be prescribed for 100 micrograms of beclometasone dipropionate, budesonide, or ﬂuticasone propionate; the dose of Qvar ® should be adjusted according to response.

PDF pages 293, 294

Safety

Important Safety Information

MHRA/CHM ADVICE (JULY 2008) Beclometasone dipropionate CFC-free pressurised metered-dose inhalers (Qvar ® and Clenil Modulite ®) are not interchangeable and should be prescribed by brand name; Qvar ® has extra-ﬁne particles, is more potent than traditional beclometasone dipropionate CFC- containing inhalers, and is approximately twice as potent as Clenil Modulite ®. MHRA/CHM ADVICE: PRESSURISED METERED DOSE INHALERS (PMDI): RISK OF AIRWAY OBSTRUCTION FROM ASPIRATION OF LOOSE OBJECTS (JULY 2018) See Respiratory system, drug delivery p. 249.

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Interactions

→Appendix 1: corticosteroids

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Side Effects

▶Common or very common Throat irritation ▶Rare or very rare Wheezing

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Inhalation powder CAUTIONARY AND ADVISORY LABELS 8, 10 ▶Easyhaler (beclometasone) (Orion Pharma (UK) Ltd) Beclometasone dipropionate 200 microgram per 1 dose Easyhaler Beclometasone 200micrograms/dose dry powder inhaler | 200 dose P £14.93 DT = £14.93 Pressurised inhalation CAUTIONARY AND ADVISORY LABELS 8, 10 ▶Clenil Modulite (Chiesi Ltd) Beclometasone dipropionate 50 microgram per 1 dose Clenil Modulite 50micrograms/dose inhaler | 200 dose P £3.70 DT = £3.70 Beclometasone dipropionate 100 microgram per 1 dose Clenil Modulite 100micrograms/dose inhaler | 200 dose P £7.42 DT = £7.42 Beclometasone dipropionate 200 microgram per 1 dose Clenil Modulite 200micrograms/dose inhaler | 200 dose P £16.17 DT = £16.17 Beclometasone dipropionate 250 microgram per 1 dose Clenil Modulite 250micrograms/dose inhaler | 200 dose P £16.29 DT = £16.29 ▶Kelhale (Cipla EU Ltd) Beclometasone dipropionate 50 microgram per 1 dose Kelhale 50micrograms/dose inhaler | 200 dose P £5.20 DT = £3.70 Beclometasone dipropionate 100 microgram per 1 dose Kelhale 100micrograms/dose inhaler | 200 dose P £5.20 DT = £7.42 ▶Qvar (Teva UK Ltd) Beclometasone dipropionate 50 microgram per 1 dose Qvar 50 inhaler | 200 dose P £7.87 DT = £3.70 Beclometasone dipropionate 100 microgram per 1 dose Qvar 100 inhaler | 200 dose P £17.21 DT = £7.42 ▶Qvar Autohaler (Teva UK Ltd) Beclometasone dipropionate 50 microgram per 1 dose Qvar 50 Autohaler | 200 dose P £7.87 DT = £7.87 Beclometasone dipropionate 100 microgram per 1 dose Qvar 100 Autohaler | 200 dose P £17.21 DT = £17.21 ▶Qvar Easi-Breathe (Teva UK Ltd) Beclometasone dipropionate 50 microgram per 1 dose Qvar 50micrograms/dose Easi-Breathe inhaler | 200 dose P £7.74 DT = £7.87 Beclometasone dipropionate 100 microgram per 1 dose Qvar 100micrograms/dose Easi-Breathe inhaler | 200 dose P £16.95 DT = £17.21 ▶Soprobec (Glenmark Pharmaceuticals Europe Ltd) Beclometasone dipropionate 50 microgram per 1 dose Soprobec 50micrograms/dose inhaler | 200 dose P £2.78 DT = £3.70 Beclometasone dipropionate 100 microgram per 1 dose Soprobec 100micrograms/dose inhaler | 200 dose P £5.57 DT = £7.42 Beclometasone dipropionate 200 microgram per 1 dose Soprobec 200micrograms/dose inhaler | 200 dose P £12.13 DT = £16.17 Beclometasone dipropionate 250 microgram per 1 dose Soprobec 250micrograms/dose inhaler | 200 dose P £12.22 DT = £16.29

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Clinical care

Patient And Carer Advice

Steroid card should be issued with high doses of inhaled beclometasone dipropionate. Medicines for Children leaflet: Beclometasone inhaler for asthma prevention (prophylaxis) www.medicinesforchildren.org.uk/ beclometasone-inhaler-asthma-prevention-prophylaxis-0 l PROFESSION SPECIFIC INFORMATION Dental practitioners’ formulary Clenil Modulite ® 50 micrograms/metered inhalation may be prescribed.

PDF page 294

Dose text by age group

Adult

200–400 micrograms twice daily; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 293

Adult

200–400 micrograms twice daily, adjusted

First-line fragment. Read the complete Indications and Dose section above.

PDF page 293

Adult

50–200 micrograms twice daily; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 293

Adult

50–200 micrograms twice daily; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 293

Adult

200 micrograms twice daily, adjusted according

First-line fragment. Read the complete Indications and Dose section above.

PDF page 293

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Beclometasone dipropionate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 293, 294

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 293

Prescribing And Dispensing Information

PDF pages 293, 294

Safety

Important Safety Information

PDF page 293

Interactions

→Appendix 1: corticosteroids

PDF page 293

Side Effects

▶Common or very common Throat irritation ▶Rare or very rare Wheezing

PDF page 293

Dose and formulations

Medicinal Forms

PDF page 294

Clinical care

Patient And Carer Advice

PDF page 294

Dose text by age group

Adult

200–400 micrograms twice daily; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 293

Adult

200–400 micrograms twice daily, adjusted

First-line fragment. Read the complete Indications and Dose section above.

PDF page 293

Adult

50–200 micrograms twice daily; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 293

Adult

50–200 micrograms twice daily; increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 293

Adult

200 micrograms twice daily, adjusted according

First-line fragment. Read the complete Indications and Dose section above.

PDF page 293

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.