Names and pronunciation
(ben-da-muss′teen) Bendeka, Treanda
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Drug reference
(ben-da-muss′teen) Bendeka, Treanda
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Func. class.: Antineoplastic alkylating agent
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USES: Chronic lymphocytic leukemia, indolent B-cell non-Hodgkin’s lymphoma that has progressed or within 6 mo use of rituximab regimen
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CONTRAINDICATIONS: Preg- nancy, fetal harm may occur; breastfeeding, children, hepatic disease, renal impairment, hypersensitivity to product or mannitol Precautions: Hyperuricemia, infusion- related reactions, myelosuppression, infection, skin reactions
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DOSAGE AND ROUTES Chronic lymphocytic leukemia • Adult: IV INFUSION 100 mg/m2 B over 30 min (Treanda) or 10 min (Bendeka) on days 1, 2 q28days up to 6 cycles Non-Hodgkin’s lymphoma • Adult: IV INFUSION 120 mg/m2 over 60 min (Treanda) or 10 min (Bendeka) on days 1, 2 q21days up to 8 cycles Mantle cell lymphoma (unlabeled) • Adult: IV INFUSION 90 mg/m2 on days 1, 2 with rituximab on day 1 q28days for 6 cycles Renal/hepatic dose • Adult: IV INFUSION CCr <30 mL/min, do not use; AST or ALT 2.5-10 × ULN or bilirubin 1.5-3 × ULN, do not use
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Available forms: Solution for injection 100-mg/4-mL vials; lyophilized powder for injection: 25-, 100-mg single-use vials See Appendix B
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• Adult: IV INFUSION 100 mg/m2 B over 30 min (Treanda) or 10 min (Bendeka) on days 1, 2 q28days up to 6 cycles Non-Hodgkin’s lymphoma
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• Adult: IV INFUSION 120 mg/m2 over 60 min (Treanda) or 10 min (Bendeka) on days 1, 2 q21days up to 8 cycles Mantle cell lymphoma (unlabeled)
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• Adult: IV INFUSION 90 mg/m2 on days 1, 2 with rituximab on day 1 q28days for 6 cycles Renal/hepatic dose
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• Adult: IV INFUSION CCr <30 mL/min, do not use; AST or ALT 2.5-10 × ULN or bilirubin 1.5-3 × ULN, do not use
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