Therapeutic Action
Long-acting penicillin antibacterial
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Drug reference
Long-acting penicillin antibacterial
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Early syphilis (primary, secondary, or early latent infection of less than 12 months duration) Late latent syphilis (infection of more than 12 months duration or of unknown duration) Congenital syphilis (absence of clinical signs in the neonate and adequate treatment in the mother) Endemic treponematoses (yaws, bejel, pinta) Streptococcal tonsillitis Prophylaxis of diphtheria in the event of direct contact Primary and secondary prophylaxis of rheumatic fever
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Do not administer to penicillin-allergic patients. Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur) and renal impairment (reduce dosage). May cause: gastroinstestinal disturbances, pain at injection site, allergic reactions sometimes severe; Jarisch-Herxheimer reaction (fever, chills, myalgia, tachycardia) in patients with syphilis; convulsions in the event of high dosages or renal impairment; symptoms of shock with neuropsychiatric disorders in case of accidental IV injection. Ensure that the IM injection does not enter a blood vessel. Do not combine with methotrexate. Pregnancy and breast-feeding: no contra-indication
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Powder for injection in vials of: 1.2 MIU (900 mg), to be dissolved in 4 ml of water for injection, for IM injection 2.4 MIU (1.8 g), to be dissolved in 8 ml of water for injection, for IM injection NEVER FOR IV INJECTION NOR INFUSION
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Syphilis Child: 50 000 IU (37.5 mg)/kg per injection (max. 2.4 MIU or 1.8 g per injection) Adult: 2.4 MIU (1.8 g) per injection Yaws, bejel, pinta Child under 10 years: 1.2 MIU (900 mg) per injection Child 10 years and over and adult: 2.4 MIU (1.8 g) per injection Streptococcal tonsillitis, prophylaxis of diphtheria, prophylaxis of rheumatic fever Child under 30 kg: 600 000 IU (450 mg) per injection Child 30 kg and over and adult: 1.2 MIU (900 mg) per injection
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Early syphilis, congenital syphilis, tonsillitis, yaws, bejel, pinta, prophylaxis of diphtheria, primary prophylaxis of rheumatic fever: single dose Late latent syphilis: one injection/week for 3 weeks Secondary prophylaxis of rheumatic fever: one injection every 4 weeks for several years
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For a 2.4 MIU (1.8 g) dose, administer 1.2 MIU (900 mg) in each buttock. Do not confuse long-acting benzathine benzylpenicillin, for IM injection, with rapidly acting benzylpenicillin (or penicillin G), administered by Iv route. Do not mix with other drugs in the same syringe.
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– – Below 25 °C Once reconstituted, suspension must be used immediately.
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50 000 IU (37.5 mg)/kg per injection (max. 2.4 MIU or 1.8 g per injection)
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2.4 MIU (1.8 g) per injection
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1.2 MIU (900 mg) per injection
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2.4 MIU (1.8 g) per injection
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600 000 IU (450 mg) per injection
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1.2 MIU (900 mg) per injection
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