Therapeutic Action
Short-acting penicillin antibacterial
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Drug reference
Short-acting penicillin antibacterial
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Diptheria, when oral treatment is not possible Severe leptospirosis, neurosyphilis Congenital syphilis (presence of clinical signs in the neonate and lack of adequate treatment in the mother)
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Do not administer to penicillin-allergic patients. Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur) and renal impairment (reduce dosage in patients with neurosyphilis). May cause: gastroinstestinal disturbances, pain at injection site, anaemia, allergic reactions sometimes severe; Jarisch-Herxheimer reaction (fever, chills, myalgia, tachycardia) in patients with syphilis; convulsions in the event of rapid IV injection, high dosages or renal impairment. Do not combine with methotrexate. Pregnancy and breast-feeding: no contra-indication
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Powder for injection in vials of: 1 MIU (600 mg), to be dissolved in 2 ml of water for injection or 0.9% sodium chloride 5 MIU (3 g), to be dissolved in 5 ml of water for injection or 0.9% sodium chloride For IM injection, or slow IV injection through an infusion tube (3 to 5 minutes), or IV infusion (60 minutes) in 0.9% sodium chloride or 5% glucose.
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Diphtheria Child: 25 000 IU (15mg)/kg (max. 1 MIU or 600 mg) by IM or IV injection every 6 hours Adult: 1 MIU (600 mg) by IM or IV injection every 6 hours Severe leptospirosis Child: 50 000 IU (30 mg)/kg (max. 2 MIU or 1200 mg) by IV injection every 6 hours Adult: 1 to 2 MIU (600 to 1200 mg) by IV injection every 6 hours Neurosyphilis Adult: 2 to 4 MIU (1200 to 2400 mg) by IV injection every 4 hours Congenital syphilis 50 000 IU (30 mg)/kg by IV injection every 12 hours from D1 to D7, then 50 000 IU (30 mg)/kg by IV injection every 8 hours from D8 to D10
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Diphtheria: change to an oral treatment as soon as the patient can swallow, to complete 14 days of treatment Severe leptospirosis: 7 days Neurosyphilis: 14 days Congenital syphilis: 10 days
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Do not confuse short-acting benzylpenicillin, administered several times a day by IV route, with long-acting penicillins (benzathine benzylpenicillin and procaine benzylpenicillin) administered by IM route only. Do not mix with other drugs in the same syringe or infusion.
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– Below 25 °C Once reconstituted, suspension must be used immediately.
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25 000 IU (15mg)/kg (max. 1 MIU or 600 mg) by IM or IV injection every 6 hours
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50 000 IU (30 mg)/kg (max. 2 MIU or 1200 mg) by IV injection every 6 hours
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