Therapeutic Action
Long-acting penicillin antibacterial (12 to 24 hours)
PDF page 370
Loading InternPractice…
Drug reference
Long-acting penicillin antibacterial (12 to 24 hours)
PDF page 370
Diphtheria, when oral treatment is not possible Congenital syphilis, if the neonate has clinical signs of syphilis or the mother did not receive adequate treatment for syphilis during pregnancy
PDF page 370
Do not administer to patients allergic to penicillin and/or procaine. Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur) or with renal impairment. May cause: gastrointestinal disturbances; allergic reactions sometimes severe. In the event of allergic reactions, stop treatment immediately. Ensure that the needle does not accidentally enter a vessel (risk of serious neurovascular damage). Pregnancy and breast-feeding: no contra-indication
PDF page 371
Powder for injection in vials of: 0.6 MIU (600 mg) vial, to be dissolved with the diluent supplied by the manufacturer (4 ml- ampoule of water for injection) 1.2 MIU (1.2 g) vial, to be dissolved with the diluent supplied by the manufacturer (5 ml-ampoule of water for injection) For IM injection only. NEVER ADMINISTER BY IV INJECTION OR INFUSION.
PDF page 370
Diphtheria Child: 50 000 IU/kg (= 50 mg/kg) once daily (max. 1.2 MIU = or 1.2 g daily) Adult: 1.2 MIU (= 1.2 g) once daily Congenital syphilis Neonate: 50 000 IU/kg (= 50 mg/kg) once daily
PDF page 370
Diphtheria: change to an oral treatment as soon as the patient can swallow, to complete 14 days of treatment Congenital syphilis: 10 days
PDF pages 370, 371
Also comes in 1 MIU, and 3 MIU and 4 MIU vials of powder for injection. Do not confuse procaine benzylpenicillin with short-acting benzylpenicillin (penicillin G), administered several times per day by IV route. Do not mix with other drugs in the same syringe.
PDF page 371
– Below 25 °C Once reconstituted, suspension must be used immediately.
PDF page 371
50 000 IU/kg (= 50 mg/kg) once daily (max. 1.2 MIU = or 1.2 g daily)
PDF page 370