Indications And Dose
Mild to moderate susceptible infections | Throat infections | Otitis media | Pneumonia | Cellulitis ▶BY INTRAMUSCULAR INJECTION, OR BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 0.6–1.2 g every 6 hours, dose may be increased if necessary in more serious infections (consult product literature), single doses over 1.2 g to be given by continued → intravenous route only Endocarditis (in combination with other antibacterial if necessary) ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1.2 g every 4 hours, increased if necessary to 2.4 g every 4 hours, dose may be increased in infections such as enterococcal endocarditis Anthrax (in combination with other antibacterials) Infection ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 2.4 g every 4 hours Intrapartum prophylaxis against group B streptococcal infection ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: Initially 3 g for 1 dose, then 1.5 g every 4 hours until delivery Meningitis | Meningococcal disease ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 2.4 g every 4 hours ▶BY INTRAVENOUS INFUSION ▶Neonate up to 7 days: 50 mg/kg every 12 hours. ▶Neonate 7 days to 28 days: 50 mg/kg every 8 hours. ▶Child: 50 mg/kg every 4–6 hours (max. per dose 2.4 g every 4 hours) Suspected meningococcal disease (meningitis with non- blanching rash or meningococcal septicaemia) prior to urgent transfer to hospital ▶BY INTRAVENOUS INJECTION, OR BY INTRAMUSCULAR INJECTION ▶Child 1–11 months: 300 mg, administer as single dose prior to urgent transfer to hospital so long as does not delay transfer ▶Child 1–9 years: 600 mg, administer as single dose prior to urgent transfer to hospital so long as does not delay transfer ▶Child 10–17 years: 1.2 g, administer as single dose prior to urgent transfer to hospital so long as does not delay transfer ▶Adult: 1.2 g, administer as single dose prior to urgent transfer to hospital so long as does not delay transfer Suspected bacterial meningitis without non-blanching rash where patient cannot be transferred to hospital urgently ▶BY INTRAVENOUS INJECTION, OR BY INTRAMUSCULAR INJECTION ▶Child 1–11 months: 300 mg, administer as single dose prior to transfer to hospital ▶Child 1–9 years: 600 mg, administer as single dose prior to transfer to hospital ▶Child 10–17 years: 1.2 g, administer as single dose prior to transfer to hospital ▶Adult: 1.2 g, administer as single dose prior to transfer to hospital l UNLICENSED USE ▶In adults Benzylpenicillin doses in the BNF may differ from those in product literature.
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