Drug reference

Bisoprolol fumarate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 187

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Hypertension | Angina ▶BY MOUTH ▶Adult: 5–10 mg once daily; maximum 20 mg per day Adjunct in heart failure ▶BY MOUTH ▶Adult: Initially 1.25 mg once daily for 1 week, dose to be taken in the morning, then increased if tolerated to 2.5 mg once daily for 1 week, then increased if tolerated to 3.75 mg once daily for 1 week, then increased if tolerated to 5 mg once daily for 4 weeks, then increased if tolerated to 7.5 mg once daily for 4 weeks, then increased if tolerated to 10 mg once daily; maximum 10 mg per day

PDF page 187

Contra Indications

Acute or decompensated heart failure requiring intravenous inotropes. sino–atrial block

PDF page 187

Cautions

Ensure heart failure not worsening before increasing dose

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Safety

Interactions

→Appendix 1: beta blockers, selective

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Side Effects

▶Common or very common Constipation ▶Uncommon Muscle cramps. muscle weakness. postural hypotension ▶Rare or very rare Allergic rhinitis. alopecia. auditory disorder. conjunctivitis. ﬂushing. hepatitis. hypersensitivity. pruritus

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Hepatic Impairment

Manufacturer advises caution. Dose adjustments ▶When used for angina or hypertension Manufacturer advises consider maximum dose of 10 mg once daily in severe impairment—consult product literature. ▶When used for heart failure Manufacturer advises caution when titrating dose (no information available).

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Renal Impairment

Dose adjustments Reduce dose if eGFR less than 20 mL/minute/1.73 m2 (max. 10 mg daily).

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet CAUTIONARY AND ADVISORY LABELS 8 ▶Bisoprolol fumarate (Non-proprietary) Bisoprolol fumarate 1.25 mg Bisoprolol 1.25mg tablets | 28 tablet P £7.43 DT = £0.96 | 100 tablet P £3.32–£6.79 Bisoprolol fumarate 2.5 mg Bisoprolol 2.5mg tablets | 28 tablet P £4.39 DT = £0.88 | 100 tablet P £3.07–£6.39 Bisoprolol fumarate 3.75 mg Bisoprolol 3.75mg tablets | 28 tablet P £4.89 DT = £1.16 Bisoprolol fumarate 5 mg Bisoprolol 5mg tablets | 28 tablet P £5.89 DT = £0.87 | 100 tablet P £3.04–£4.25 Bisoprolol fumarate 7.5 mg Bisoprolol 7.5mg tablets | 28 tablet P £5.89 DT = £1.21 Bisoprolol fumarate 10 mg Bisoprolol 10mg tablets | 28 tablet P £0.99 DT = £0.99 | 100 tablet P £3.50–£4.50 ▶Cardicor (Merck Serono Ltd) Bisoprolol fumarate 1.25 mg Cardicor 1.25mg tablets | 28 tablet P £2.35 DT = £0.96 Bisoprolol fumarate 2.5 mg Cardicor 2.5mg tablets | 28 tablet P £2.35 DT = £0.88 Cardiovascular system Bisoprolol fumarate 3.75 mg Cardicor 3.75mg tablets | 28 tablet P £4.90 DT = £1.16 Bisoprolol fumarate 5 mg Cardicor 5mg tablets | 28 tablet P £5.90 DT = £0.87 Bisoprolol fumarate 7.5 mg Cardicor 7.5mg tablets | 28 tablet P £5.90 DT = £1.21 Bisoprolol fumarate 10 mg Cardicor 10mg tablets | 28 tablet P £5.90 DT = £0.99 eiiii F 159

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Dose text by age group

Adult

5–10 mg once daily; maximum 20 mg per day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 187

Adult

Initially 1.25 mg once daily for 1 week, dose to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 187

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Bisoprolol fumarate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 187

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 187

Contra Indications

Acute or decompensated heart failure requiring intravenous inotropes. sino–atrial block

PDF page 187

Cautions

Ensure heart failure not worsening before increasing dose

PDF page 187

Safety

Interactions

→Appendix 1: beta blockers, selective

PDF page 187

Side Effects

PDF page 187

Hepatic Impairment

PDF page 187

Renal Impairment

Dose adjustments Reduce dose if eGFR less than 20 mL/minute/1.73 m2 (max. 10 mg daily).

PDF page 187

Dose and formulations

Medicinal Forms

PDF page 187

Dose text by age group

Adult

5–10 mg once daily; maximum 20 mg per day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 187

Adult

Initially 1.25 mg once daily for 1 week, dose to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 187

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.