Therapeutic Action
Cardioselective beta-blocker
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Drug reference
Cardioselective beta-blocker
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Hypertension, treatment of chronic stable angina pectoris Chronic stable heart failure in combination with a converting enzyme inhibitor (enalapril)
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Do not administer to patients with asthma, chronic obstructive bronchopneumonia, acute heart failure, severe hypotension, bradycardia < 50/minute, atrio-ventricular heart blocks, Raynaud's syndrome. May cause: bradycardia, hypotension, worsening of heart failure (reduce dose); bronchospasm in patients with an obstructive respiratory disease; hypoglycaemia, gastrointestinal disturbances, headache, fatigue, muscle weakness, erectile dysfunction. Administer with caution to patients with diabetes (risk of hypoglycaemia). In the event of anaphylactic shock, risk of resistance to epinephrine. Avoid or monitor combination with: mefloquine, digoxin, amiodarone, diltiazem, verapamil (risk of bradycardia); tricyclic antidepressants, antipsychotics, anti-hypertensive drugs (risk of hypotension). Pregnancy and breast-feeding: use labetalol, particularly for the management of hypertension in pregnancy.
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2.5 mg breakable tablet 10 mg breakable in ¼ tablet
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Hypertension, angina pectoris Adult: 5 to 10 mg once daily, preferably in the morning (max. 20 mg daily) In patients with renal or hepatic impairment: start with 2.5 mg once daily then increase, if necessary, according to clinical response (max. 10 mg daily) Heart failure Adult: start with 1.25 mg once daily and increase according to the table below, as long as the drug is well tolerated (heart rate, blood pressure, signs of worsening heart failure) Weeks Daily dose Tablet(s) Week 1 1.25 mg once daily 2.5 mg tab: ½ tab daily 2.5 mg tab: 1 tab daily Week 2 2.5 mg once daily or 10 mg tab: ¼ tab daily Week 3 3.75 mg once daily 2.5 mg tab: 1½ tab daily Week 4 to 8 5 mg once daily 10 mg tab: ½ tab daily 2.5 mg tab: 1 tab daily + 10 mg tab: ½ tab daily Week 9 to 12 7.5 mg once daily or 10 mg tab: ¾ tab daily 10 mg once daily From week 13 10 mg tab: 1 tab daily (max. 10 mg daily)
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According to clinical response. Do not stop treatment abruptly, decrease doses gradually.
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– – Below 25 °C
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5 to 10 mg once daily, preferably in the morning (max. 20 mg daily)
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start with 1.25 mg once daily and increase according to the table below, as long as the drug is well tolerated (heart rate, blood pressure, signs of worsening heart failure)
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