Drug reference
Spasmodic torticollis (cervical dystonia) (specialist use only) ▶BY INTRAMUSCULAR INJECTION ▶Adult: Initially 5000–10 000 units, adjusted according to response, dose to be divided between 2–4 most affected muscles DOSE EQUIVALENCE AND CONVERSION ▶Important: information specific to each individual preparation.
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Neuromuscular disorders. neuromuscular junctional disorders
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History of dysphagia or aspiration. off-label use (risk of toxin spread). tolerance may occur
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Important: not interchangeable with other botulinum toxin preparations.
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→Appendix 1: botulinum toxins
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▶Common or very common Dry mouth. dysphagia. dysphonia. headache. influenza like illness. muscle weakness. neck pain. taste altered. vision disorders ▶Frequency not known Angioedema. asthenia. constipation . dyspnoea. pneumonia aspiration. ptosis. skin reactions. vomiting
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Low risk of systemic absorption but avoid unless essential.
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Low risk of systemic absorption but avoid unless essential.
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Injection may be diluted with sodium chloride 0.9%.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶NeuroBloc (Sloan Pharma Sarl) Botulinum toxin type B 5000 unit per 1 ml NeuroBloc 5,000units/1ml solution for injection vials | 1 vial P £148.27 (Hospital only) NeuroBloc 10,000units/2ml solution for injection vials | 1 vial P £197.69 (Hospital only) NeuroBloc 2,500units/0.5ml solution for injection vials | 1 vial P £111.20 (Hospital only) NEUROPROTECTIVE DRUGS
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Patients should be warned of the signs and symptoms of toxin spread, such as muscle weakness and breathing difficulties; they should be advised to seek immediate medical attention if swallowing, speech or breathing difficulties occur.
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Initially 5000–10 000 units, adjusted according
First-line fragment. Read the complete Indications and Dose section above.
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