Drug reference
Adjunct in the treatment of opioid dependence (dose expressed as buprenorphine) ▶BY SUBLINGUAL ADMINISTRATION ▶Adult: Initially 2–4 mg once daily, an additional dose of 2–4 mg may be administered on day 1 depending on the individual patient’s requirement, increased in steps of 2–8 mg, adjusted according to response, total weekly dose may be divided and given on alternate days or 3 times weekly; maximum 24 mg per day
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Scottish Medicines Consortium (SMC) decisions SMC No. 355/07 The Scottish Medicines Consortium has advised (March 2007) that buprenorphine/naloxone (Suboxone ®) is accepted for restricted use within NHS Scotland for substitution treatment for opioid drug dependance, within a framework of medical, social and psychological treatment in whom methadone is not suitable.
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→Appendix 1: opioids
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There can be variation in the licensing of different medicines containing the same drug. Sublingual tablet CAUTIONARY AND ADVISORY LABELS 2, 26 ▶Buprenorphine with naloxone (Non-proprietary) Naloxone (as Naloxone hydrochloride dihydrate) 500 microgram, Buprenorphine (as Buprenorphine hydrochloride) 2 mg Buprenorphine 2mg / Naloxone 500microgram sublingual tablets sugar-free | 28 tablet P £25.60 DT = £25.60 c Naloxone (as Naloxone hydrochloride dihydrate) 2 mg, Buprenorphine (as Buprenorphine hydrochloride) 8 mg Buprenorphine 8mg / Naloxone 2mg sublingual tablets sugar- free | 28 tablet P £76.73 DT = £76.73 c ▶Suboxone (Indivior UK Ltd) Naloxone (as Naloxone hydrochloride dihydrate) 500 microgram, Buprenorphine (as Buprenorphine hydrochloride) 2 mg Suboxone 2mg/500microgram sublingual tablets sugar-free | 28 tablet P £25.40 DT = £25.60 c Naloxone (as Naloxone hydrochloride dihydrate) 2 mg, Buprenorphine (as Buprenorphine hydrochloride) 8 mg Suboxone 8mg/2mg sublingual tablets sugar-free | 28 tablet P £76.19 DT = £76.73 c Naloxone (as Naloxone hydrochloride dihydrate) 4 mg, Buprenorphine (as Buprenorphine hydrochloride) 16 mg Suboxone 16mg/4mg sublingual tablets sugar-free | 28 tablet P £152.38 DT = £152.38 c SYMPATHOMIMETICS › ALPHA2-ADRENOCEPTOR AGONISTS
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Initially 2–4 mg once daily, an additional dose of
First-line fragment. Read the complete Indications and Dose section above.
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