Names and pronunciation
(bur-oh′sue-mab) Crysvita
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Drug reference
(bur-oh′sue-mab) Crysvita
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Func. class.: Fibroblast growth factor blocking antibody
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USES: X-linked hypophosphatemia (XLH) in adult and pediatric patients 1 yr of age and older
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CONTRAINDICATIONS: Use with oral phosphate or active vitamin D analogs; serum phosphorus is within or above the normal range for age; severe renal impairment or end-stage renal disease
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DOSAGE AND ROUTES •Adult: SUBCUT 1 mg/kg body weight rounded to nearest 10 mg (max 90 mg) q4wk • Child 1-18 yr: SUBCUT 0.8 mg/kg body weight rounded to nearest 10 mg (max 90 mg) q2wk. Dose may be increased up to approximately 2 mg/kg (max 90 mg) q2wk to achieve normal serum phosphorus
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Available forms: Solution for injection 10, 20, 30 mg/mL HIGH ALERT
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•Adult: SUBCUT 1 mg/kg body weight rounded to nearest 10 mg (max 90 mg) q4wk
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• Child 1-18 yr: SUBCUT 0.8 mg/kg body weight rounded to nearest 10 mg (max 90 mg) q2wk. Dose may be increased up to approximately 2 mg/kg (max 90 mg) q2wk to achieve normal serum phosphorus
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